Complex Event Analysis - Report 2020/02/27

Momentum supporting factors

  • (chemotherapy, colon, resected, risk)
  • (chemotherapy, clinicopathologic, colon, resected)
  • (chemotherapy, resected, stratification)
  • (chemotherapy, colon, resected, stratification)
  • (colon, colorectal, preoperative)
  • (colon, preoperative)
  • (colon, colorectal, preoperative, resection)
  • (colon, preoperative, resection)
  • (colorectal, preoperative, resection)
  • (preoperative, resection)

    • Challenge supporting factors

  • (chemotherapy, colon, iii, resected)
  • (colon, iii, risk)
  • (adjuvant, chemotherapy, colon, iii)
  • (adjuvant, chemotherapy, colon, risk)
  • (chemotherapy, colon, tumor)
  • (colon, postoperative, resection)
  • (adjuvant, tumor)
  • (adjuvant, chemotherapy, tumor)
  • (colon, colorectal, metastases)
  • (colon, fluorouracil, iii)

    • Work-in-progress supporting factors

  • (chemotherapy, colon, resection)
  • (chemotherapy, colon, resected, risks)
  • (chemotherapy, treatment-related)
  • (adjuvant, treatment-related)
  • (adjuvant, chemotherapy, treatment-related)
  • (adjuvant, colon, treatment-related)
  • (adjuvant, chemotherapy, colon, treatment-related)
  • (chemotherapy, colon, treatment-related)
  • (resected, risk)
  • (colon, resected, risk)

    • Complex Event Time Series Summary - REPORT


    Time PeriodChallengeMomentumWIP
    Report 2020/02/2736.19 8.25 55.56

    High Level Abstraction (HLA) combined

    High Level Abstraction (HLA)Report 2020/02/27
    (1) (chemotherapy,colon,iii,resected)100.00
    (2) (chemotherapy,colon,resection)84.24
    (3) (adjuvant,chemotherapy,colon,risk)83.64
    (4) (adjuvant,chemotherapy,colon,iii)82.34
    (5) (chemotherapy,colon,tumor)76.46
    (6) (adjuvant,chemotherapy,tumor)74.64
    (7) (colon,preoperative)70.54
    (8) (adjuvant,chemotherapy,colon,resected)67.55
    (9) (adjuvant,tumor)65.78
    (10) (clinicopathologic,colon,tumor)65.21
    (11) (chemotherapy,colon,resected,risks)65.07
    (12) (chemotherapy,treatment-related)64.95
    (13) (chemotherapy,colon,resected,risk)63.19
    (14) (adjuvant,treatment-related)62.71
    (15) (adjuvant,chemotherapy,treatment-related)62.67
    (16) (chemotherapy,clinicopathologic,colon,resected)60.91
    (17) (chemotherapy,colon,postoperative)60.86
    (18) (colon,iii,risk)60.06
    (19) (chemotherapy,clinicopathologic,tumor)59.03
    (20) (adjuvant,risk)58.52
    (21) (adjuvant,chemotherapy,risk)58.48
    (22) (chemotherapy,risk,tumor)58.02
    (23) (adjuvant,colon,risk)57.97
    (24) (chemotherapy,colon,risk)56.94
    (25) (adjuvant,colon,resected,risk)56.69
    (26) (adjuvant,colon,tumor)56.41
    (27) (colon,risk,tumor)56.32
    (28) (adjuvant,chemotherapy,colon,tumor)56.26
    (29) (risk,tumor)55.50
    (30) (chemotherapy,clinicopathologic,risk)54.50
    (31) (adjuvant,clinicopathologic,colon)54.21
    (32) (adjuvant,chemotherapy,clinicopathologic,colon)54.04
    (33) (adjuvant,colon,treatment-related)53.72
    (34) (chemotherapy,clinicopathologic,colon)53.71
    (35) (adjuvant,chemotherapy,colon,treatment-related)53.58
    (36) (clinicopathologic,colon,risk)53.23
    (37) (chemotherapy,colon,treatment-related)53.11
    (38) (clinicopathologic,risk)53.01
    (39) (colon,colorectal,metastases)52.59
    (40) (adjuvant,colon,iii)52.21
    (41) (colon,iii,oxaliplatin,resected)51.09
    (42) (resected,risk)44.98
    (43) (colon,resected,risk)44.51
    (44) (cancers,colon,oxaliplatin-based)43.83
    (45) (chemotherapy,colon,oxaliplatin-based)43.50
    (46) (colon,resection,risk)42.86
    (47) (resection,risk)42.79
    (48) (colon,diarrhea,iii,resected)42.15
    (49) (adjuvant,colon,iii,resected)42.11
    (50) (preoperative,resection)41.60
    (51) (colon,metastases,tumor)41.20
    (52) (adjuvant,chemotherapy,risks)40.80
    (53) (neutropenia,resected)40.06
    (54) (chemotherapy,colon,unresectable)39.46
    (55) (colon,colorectal,preoperative,resection)38.58
    (56) (colon,colorectal,metastases,resection)37.91
    (57) (colon,postoperative,resection)37.45
    (58) (colon,iii,oxaliplatin)36.87
    (59) (colon,preoperative,resection)36.62
    (60) (colon,oxaliplatin,resected)36.55
    (61) (iii,oxaliplatin,resected)36.52
    (62) (oxaliplatin,resected)36.51
    (63) (adjuvant,chemotherapy,iii)36.38
    (64) (colon,metastases,resection)36.18
    (65) (colon,iii,neutropenia)36.03
    (66) (colon,iii,neutropenia,resected)35.92
    (67) (colon,neutropenia,resected)35.77
    (68) (iii,neutropenia,resected)35.74
    (69) (chemoradiotherapy,colon,resection)35.51
    (70) (colon,iii,infusional)35.44
    (71) (colon,iii,infusional,resected)35.33
    (72) (iii,infusional,resected)35.25
    (73) (colectomy,colon,resection)34.42
    (74) (candidates,colon,resection)34.20
    (75) (colon,fluorouracil,iii)33.86
    (76) (chemotherapy,iii,resected)33.50
    (77) (chemotherapy,mismatch,tumor)33.12
    (78) (colon,colorectal,mismatch)32.97
    (79) (chemotherapy,resected,risks)32.87
    (80) (adjuvant,colon,risks)32.84
    (81) (resection,tumor)32.78
    (82) (adjuvant,chemotherapy,colon,risks)32.77
    (83) (cancers,colon,colorectal)32.54
    (84) (adjuvant,colon,resected,risks)32.35
    (85) (colon,resected,risks)32.23
    (86) (resected,risks)32.22
    (87) (chemotherapy,resected,risk)32.01
    (88) (colon,colorectal,nonpolyposis)31.82
    (89) (colon,colorectal,metastatic)31.41
    (90) (colon,rectal)31.18
    (91) (colon,colorectal,markers)31.12
    (92) (chemotherapy,clinicopathologic,resected)31.10
    (93) (chemotherapy,resected,tumor-related)30.10
    (94) (adjuvant,colon,resected,tumor-related)29.95
    (95) (chemotherapy,resected,tumor)29.66
    (96) (adjuvant,iii,resection)29.58
    (97) (chemotherapy,colon,resected,tumor)29.38
    (98) (bolus,colon,iii,resected)29.35
    (99) (adjuvant,colon,resected,tumor)29.14
    (100) (colon,metastases,preoperative)28.91
    (101) (chemotherapy,resected,treatment-related)28.85
    (102) (colorectal,tumor)28.83
    (103) (chemotherapy,colon,resected,treatment-related)28.51
    (104) (adjuvant,colon,resected,treatment-related)28.27
    (105) (colon,mismatch,tumor)28.17
    (106) (chemotherapy,colorectal,tumor)28.14
    (107) (chemotherapy,resected,stratification)28.13
    (108) (chemotherapy,colon,resected,stratification)28.11
    (109) (chemotherapy,perineural,resected)27.96
    (110) (chemotherapy,colon,perineural,resected)27.93
    (111) (adjuvant,colon,perineural,resected)27.80
    (112) (colorectal,metastases,tumor)27.76
    (113) (cancers,colectomy,resection)27.38
    (114) (cancers,colectomy,colon)27.32
    (115) (arm,colon,iii,resected)27.22
    (116) (chemoradiotherapy,chemotherapy)27.02
    (117) (colon,geriatric,resected)26.57
    (118) (adjuvant,iii,risk)26.40
    (119) (chemotherapy,iii,risk)26.19
    (120) (chemotherapy,colon,iii,risk)25.66
    (121) (colorectal,metastases,resection)25.42
    (122) (colon,iii,posttreatment)25.05
    (123) (adjuvant,chemotherapy,preoperative)24.61
    (124) (adjuvant,colon,preoperative)24.49
    (125) (cancers,colon,preoperative)24.41
    (126) (colon,colorectal,tumor)24.39
    (127) (adjuvant,chemotherapy,colon,preoperative)24.33
    (128) (colorectal,metastases,preoperative)24.24
    (129) (colorectal,preoperative,resection)24.16
    (130) (metastases,preoperative,resection)24.14
    (131) (adjuvant,oxaliplatin-based)24.08
    (132) (cancers,oxaliplatin-based)24.05
    (133) (adjuvant,chemotherapy,oxaliplatin-based)24.03
    (134) (colon,nodes,tumor)23.95
    (135) (chemoradiotherapy,chemotherapy,resection)23.94
    (136) (chemotherapy,colorectal,metastases)23.93
    (137) (adjuvant,colon,oxaliplatin-based)23.92
    (138) (adjuvant,chemotherapy,colon,oxaliplatin-based)23.75
    (139) (chemoradiotherapy,resection)23.68
    (140) (colon,metastasis,tumor)23.51
    (141) (chemotherapy,metastases,tumor)23.49
    (142) (chemotherapy,resection,tumor)23.15
    (143) (adjuvant,chemotherapy,colon,volume)22.84
    (144) (chemotherapy,colon,iii,oxaliplatin-containing)22.67
    (145) (colon,lymphovascular,risk)22.64
    (146) (chemotherapy,colon,iii,oxaliplatin)22.55
    (147) (chemotherapy,colon,iii,neutropenia)22.26
    (148) (colon,histology,risk)22.07
    (149) (chemotherapy,colon,iii,intravenously)21.96
    (150) (chemotherapy,colon,iii,infusional)21.84
    (151) (chemotherapy,colon,fluorouracil,iii)21.60
    (152) (chemotherapy,iii,tumor)21.50
    (153) (chemotherapy,colon,fluoropyrimidines,iii)21.42
    (154) (cancers,chemotherapy,colon)21.09
    (155) (colorectal,palliation,resection)20.96
    (156) (colorectal,national_comprehensive_cancer_network,resection)20.77
    (157) (cancers,colon,resection)20.54
    (158) (adjuvant,iii,postoperative)20.50
    (159) (chemotherapy,postoperative,resection)20.43
    (160) (chemotherapy,metastases,resection)20.43
    (161) (chemotherapy,curative,resection)19.58
    (162) (cancers,colon,nonobstructed)19.57
    (163) (colon,resection,unresectable)19.53
    (164) (colon,colorectal,preoperative)19.51
    (165) (chemotherapy,colorectal,resection)18.90
    (166) (colon,lesions,metastases)18.83
    (167) (colon,colorectal,long-term)18.76
    (168) (colon,colorectal,long-term,resection)18.68
    (169) (colorectal,long-term,resection)18.60
    (170) (colon,metastases,visualized)18.54
    (171) (colon,colorectal,resection,visualized)18.51
    (172) (colorectal,metastases,visualized)18.44
    (173) (colon,colorectal,resection,tomography)18.41
    (174) (colon,colorectal,pelvic,resection)18.34
    (175) (colon,colorectal,palliation,resection)18.26
    (176) (colorectal,manifestations,nonpolyposis)18.22
    (177) (colon,colorectal,nontherapeutic,resection)18.16
    (178) (colon,colorectal,national_comprehensive_cancer_network,resection)18.09
    (179) (cancers,nonpolyposis)18.09
    (180) (colon,colorectal,medical_oncology,resection)17.99
    (181) (cancers,risk)17.96
    (182) (cancers,colorectal,nonpolyposis)17.89
    (183) (colon,resection,tumor)16.96
    (184) (colorectal,manifestations)16.85
    (185) (adjuvant,chemotherapy,resection)16.46
    (186) (colon,colorectal,rectal)16.10
    (187) (adjuvant,oxaliplatin)15.63
    (188) (colon,colorectal,manifestations)15.45
    (189) (adjuvant,colon,rectal)15.31
    (190) (adjuvant,colon,rectal,resected)15.16
    (191) (adjuvant,chemotherapy,resected)15.14
    (192) (colon,rectal,resected)15.04
    (193) (rectal,resected)15.03
    (194) (adjuvant,colon,resected,transmural)14.90
    (195) (bolus,colon,iii)14.82
    (196) (bolus,colon,resected)14.76
    (197) (bolus,resected)14.58
    (198) (bolus,iii,resected)14.58
    (199) (adjuvant,iii,oxaliplatin)14.54
    (200) (diarrhea,resected)14.49

    Complex Event Analysis - REPORT 2020/02/27

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    Supporting narratives:

    • momentum (Read more)
      • (See "Adjuvant chemotherapy for resected stage II colon cancer", section on 'Risk stratification'and "Adjuvant chemotherapy for resected stage II colon cancer", section on 'Choice of regimen'and "Adjuvant therapy for resected colon cancer in older adult patients", section on 'Challenges specific to older adults'and 'Side effects'below.)
        Web-based tools are available that can aid the clinician in estimating the risk of recurrence and death based on clinicopathologic features, comorbidity, and the relative benefits of specific chemotherapy regimens
      • High Level Abstractions:
        • (chemotherapy,colon,resected,risk)
        • (chemotherapy,clinicopathologic,colon,resected)
        • Inferred entity relationships (161)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (colon,iii,infusional) [inferred]
        • (clinicopathologic,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (clinicopathologic,colon,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (resected,risk) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (clinicopathologic,colon,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (risk,service) [inferred]

    • momentum (Read more)
      • For patients receiving a non-oxaliplatin-based adjuvant therapy regimen (ie, a fluoropyrimidine alone), six months of adjuvant therapy remains the standard approach. (See "Adjuvant chemotherapy for resected stage II colon cancer", section on 'Risk stratification'and "Adjuvant chemotherapy for resected stage II colon cancer", section on 'Choice of regimen'and "Adjuvant therapy for resected colon cancer in older adult patients", section on 'Challenges specific to older adults'and 'Side effects'below.)
        Web-based tools are available that can aid the clinician in estimating the risk of recurrence and death based on clinicopathologic features, comorbidity, and the relative benefits of specific chemotherapy regimens
      • High Level Abstractions:
        • (chemotherapy,colon,resected,stratification)
        • (chemotherapy,resected,stratification)
        • Inferred entity relationships (156)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (resected,risk) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • momentum (Read more)
      • (See 'Metastatic disease'below and "Locoregional methods for management and palliation in patients who present with stage IV colorectal cancer", section on 'Management of the primary cancer'and "Surgical resection of primary colon cancer", section on 'Preoperative evaluation'.)
        The necessity of preoperative abdominal/pelvic CT for all patients with colon cancer is controversial, as is the clinical benefit of a staging chest CT. Nevertheless, the standard practice at most institutions is that all patients with stage II, III, or IV colon cancer undergo chest, abdomen, and pelvic CT either prior to or following resection, an approach that is endorsed by the National Comprehensive Cancer Network (NCCN) [3], the American Society of Clinical Oncology (ASCO), and the European Society for Medical Oncology (ESMO)
      • High Level Abstractions:
        • (colon,colorectal,pelvic,resection)
        • (colon,preoperative,resection)
        • (colorectal,national_comprehensive_cancer_network,resection)
        • (colorectal,palliation,resection)
        • (colorectal,preoperative,resection)
        • (colon,colorectal,preoperative)
        • (colon,colorectal,national_comprehensive_cancer_network,resection)
        • (colon,colorectal,palliation,resection)
        • (colon,preoperative)
        • (colon,colorectal,preoperative,resection)
        • (preoperative,resection)
        • Inferred entity relationships (101)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • momentum (Read more)
      • (See 'Metastatic disease'below and "Locoregional methods for management and palliation in patients who present with stage IV colorectal cancer", section on 'Management of the primary cancer'and "Surgical resection of primary colon cancer", section on 'Preoperative evaluation'.)
        The necessity of preoperative abdominal/pelvic CT for all patients with colon cancer is controversial, as is the clinical benefit of a staging chest CT. Nevertheless, the standard practice at most institutions is that all patients with stage II, III, or IV colon cancer undergo chest, abdomen, and pelvic CT either prior to or following resection, an approach that is endorsed by the National Comprehensive Cancer Network (NCCN) [3], the American Society of Clinical Oncology (ASCO), and the European Society for Medical Oncology (ESMO).
      • High Level Abstractions:
        • (colon,colorectal,medical_oncology,resection)
        • Inferred entity relationships (99)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • momentum (Read more)
      • (See "Surgical resection of primary colon cancer", section on 'Colonic obstruction'.)
        Laparoscopic-assisted colectomy, rather than open colectomy, is favored for patients with nonobstructed, nonperforated, non-locally advanced colon cancers who have not had prior extensive abdominal surgery
      • High Level Abstractions:
        • (cancers,colectomy,resection)
        • (cancers,colon,resection)
        • (cancers,colectomy,colon)
        • (cancers,colon,nonobstructed)
        • (colectomy,colon,resection)
        • Inferred entity relationships (113)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colon,metastases,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (resection,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colectomy,colon,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (cancers,colon,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (cancers,resection,stalk) [inferred]

    • momentum (Read more)
      • (See "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Cancer screening and management", section on 'General measures'.)
        The development of one or more of these cancers in a family member of a colon cancer survivor may prompt consideration for genetic testing.
      • High Level Abstractions:
        • (cancers,colon,colorectal)
        • Inferred entity relationships (138)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colon,metastases,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (cancers,loss) [inferred]
        • (colorectal,tumor) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (colorectal,risk) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (cancers,colon,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (cancers,resection,stalk) [inferred]

    • momentum (Read more)
      • (See "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Cancer screening and management", section on 'General measures'.)
        The development of one or more of these cancers in a family member of a colon cancer survivor may prompt consideration for genetic testing
      • High Level Abstractions:
        • (colon,colorectal,nonpolyposis)
        • (cancers,nonpolyposis)
        • (cancers,colorectal,nonpolyposis)
        • Inferred entity relationships (139)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (nonpolyposis,risk) [inferred]
        • (colorectal,loss) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colon,metastases,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (cancers,loss) [inferred]
        • (colorectal,tumor) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (colorectal,risk) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (cancers,colon,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (cancers,resection,stalk) [inferred]

    • momentum (Read more)
      • (See "Adjuvant therapy for resected colon cancer in older adult patients" and "Comprehensive geriatric assessment".)
        Side effects. Chemotherapy carries a risk of significant toxicities, including mucositis, emesis, diarrhea, febrile neutropenia, fatigue, hair loss, hand-foot syndrome (a condition in which there is soreness, redness, and peeling of the skin of the palms and soles of the feet), and cardiotoxicity
      • High Level Abstractions:
        • (chemotherapy,febrile,risk)
        • (chemotherapy,mucositis,risk)
        • (chemotherapy,risk,toxicities)
        • (chemotherapy,emesis,risk)
        • Inferred entity relationships (87)
        • (chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (risk,service) [inferred]

    • momentum (Read more)
      • If full colonoscopy cannot be performed because of obstruction or poor preparation, CT or magnetic resonance colonography can be done, or alternatively, the entire residual colon should be examined colonoscopically soon after resection. (See 'Colonoscopy'above.)
        .A family history of colorectal and other extracolonic cancers should be sought prior to therapy, as an inherited predisposition to colon cancer may alter the surgical approach, prompting consideration of subtotal or total colectomy in high-risk individuals
      • High Level Abstractions:
        • (cancers,colorectal,extracolonic)
        • (colonoscopically,colorectal,resection)
        • Inferred entity relationships (71)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (resection,risk) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colorectal,manifestations) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colorectal,tumor) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (resection,tumor) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (cancers,polyp) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]
        • (colorectal,risk) [inferred]

    • momentum (Read more)
      • However, increasingly, universal testing of all colorectal cancers for MSI or loss of MMR proteins by IHC is performed, a practice that is supported by guidelines from the American Society of Clinical Oncology (ASCO), the European Society for Medical Oncology (ESMO), and the United States Multi-Society Task Force on Colorectal Cancer [4-6]:
        .Absence of MSI and intact expression of all four MMR proteins on IHC rules out Lynch syndrome.
        .Although over 90 percent of Lynch syndrome-related colorectal cancers will demonstrate MSI, 15 percent of sporadic colorectal cancers also have MSI. Thus, the finding of MSI in a colorectal cancer does not indicate Lynch syndrome but, instead, identifies those patients who should be referred for additional testing (IHC or germline mutational testing).
        .For individuals with evidence of high MSI (MSI-H) or loss of expression of an MMR protein by IHC, further evaluation is based on the MSI/IHC results and is outlined in the suggested algorithm (algorithm 1):
        .Absence of protein expression of MLH1 and PMS2, MLH1 alone, or PMS2 alone (which is rare) may be associated with either sporadic or inherited disease
      • High Level Abstractions:
        • (colorectal,mmr)
        • (cancers,msi)
        • (cancers,colorectal,pms)
        • (cancers,colorectal,loss)
        • (cancers,loss)
        • (colorectal,msi)
        • (cancers,mmr)
        • (cancers,colorectal,msi)
        • (cancers,colorectal,ihc)
        • (cancers,colorectal,mmr)
        • (cancers,colorectal,individuals)
        • (cancers,colorectal,sporadic)
        • (colorectal,loss)
        • Inferred entity relationships (72)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,loss) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (individuals,security) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (individuals,monetary,policy) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colorectal,manifestations) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colorectal,tumor) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,mmr) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]
        • (colorectal,risk) [inferred]

    • momentum (Read more)
      • (See "Adjuvant therapy for resected colon cancer in older adult patients".)
        Management of carcinoma in a polyp. The majority of colon cancers arise from polyps (adenomas). Benign adenomas, as well as those with severe dysplasia or carcinoma in situ (no evidence of invasive cancer, defined as invasion into the submucosa), can be effectively managed by endoscopic removal (polypectomy) alone as long as the resection margins are free of cancer
      • High Level Abstractions:
        • (cancers,polyp)
        • (cancers,carcinoma)
        • Inferred entity relationships (43)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,histology,resection) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (polyp,risk) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (cancers,mmr) [inferred]
        • (polyp,resection) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]

    • momentum (Read more)
      • Endoscopic resection is a reasonable alternative to radical surgery for selected early stage colon cancers arising in a polyp, as long as they meet certain criteria for favorable risk. (See 'Surgical resection'above and 'Management of carcinoma in a polyp'above.)
        There is no consensus as to which patients, if any, are suitable for neoadjuvant approaches rather than upfront surgery
      • High Level Abstractions:
        • (cancers,polyp)
        • (polyp,risk)
        • (cancers,risk)
        • (cancers,carcinoma)
        • Inferred entity relationships (45)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (risk,tumor) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (cancers,histology,resection) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (polyp,risk) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,mmr) [inferred]
        • (polyp,resection) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (risk,service) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]

    • momentum (Read more)
      • Results from the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) collaboration (six randomized trials of six versus three months of oxaliplatin-based adjuvant therapy) suggest that six months of therapy remains the standard of care for individuals with high-risk cancers (T4 or N2 (table 1)) [16]. On the other hand, given the small predicted loss of absolute disease-free survival benefit (absolute difference 0.9 percent at three years) and the significantly lower rates of oxaliplatin neuropathy seen in the IDEA collaboration analysis, adjuvant therapy can be limited to three months in patients with low-risk disease (T1-3N1), which makes up approximately 60 percent of all stage III colon cancers
      • High Level Abstractions:
        • (cancers,loss)
        • Inferred entity relationships (40)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,histology,resection) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]

    • challenge (Read more)
      • However, use of this program is not a substitute for clinical judgment and careful consideration of all relevant patient- and tumor-related factors that may impact the decision to pursue adjuvant therapy. (See "Adjuvant chemotherapy for resected stage II colon cancer", section on 'Web-based tools'.)
        In general, older adult patients gain as much benefit from adjuvant FU-based chemotherapy as do younger individuals, although it is used less often in older adults, and rates of treatment-related toxicity may be higher
      • High Level Abstractions:
        • (adjuvant,chemotherapy,resected)
        • (adjuvant,chemotherapy,colon,resected)
        • (chemotherapy,resected,tumor-related)
        • (adjuvant,colon,resected,tumor-related)
        • Inferred entity relationships (214)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • (See "Adjuvant therapy for resected stage III (node-positive) colon cancer".)
        Most treatments involve a combination of several chemotherapy drugs, which are given intravenously in a specific order on specific days
      • High Level Abstractions:
        • (colon,iii,risk)
        • (chemotherapy,iii,resected)
        • (chemotherapy,colon,iii,resected)
        • Inferred entity relationships (163)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (resected,risk) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (risk,service) [inferred]

    • challenge (Read more)
      • (See "Adjuvant therapy for resected colon cancer in older adult patients", section on 'Oxaliplatin-based regimens'and "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Oxaliplatin-based therapy'.)
        The optimal duration of oxaliplatin-containing chemotherapy is evolving
      • High Level Abstractions:
        • (chemotherapy,colon,iii,resected)
        • Inferred entity relationships (160)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (resected,risk) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • The benefits of adjuvant chemotherapy have been most clearly demonstrated in patients with stage III (node-positive) disease, who have an approximately 30 percent reduction in the risk of disease recurrence and a 22 to 32 percent reduction in mortality with modern chemotherapy
      • High Level Abstractions:
        • (colon,iii,risk)
        • (adjuvant,chemotherapy,iii)
        • (adjuvant,iii,resected)
        • (adjuvant,chemotherapy,colon,iii)
        • (adjuvant,colon,iii,resected)
        • (adjuvant,colon,iii)
        • Inferred entity relationships (221)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (iii,resected,venous) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (risk,service) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • Prognostic factors for outcome in patients with recurrent colon cancer were addressed in a large database series of 17,381 patients who were enrolled in 18 randomized phase III trials testing adjuvant chemotherapy for stage II or III colon cancer conducted mainly before 2000 in the era when treatment was mainly limited to fluorouracil (FU) [35]
      • High Level Abstractions:
        • (adjuvant,chemotherapy,colon,iii)
        • (adjuvant,colon,iii)
        • Inferred entity relationships (217)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (iii,resected,venous) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • Five-year survival rates according to tumor stage at diagnosis for patients with colon cancer, derived from the population-based Surveillance, Epidemiology, and End Results (SEER) database and stratified according to the current 2010 American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) tumor, node, metastasis (TNM) staging classification, are illustrated in the figure (figure 2) [25].
        For individual patients, a postoperative nomogram has been developed that permits prediction of the risk of a colon cancer recurrence based upon clinicopathologic factors and whether adjuvant chemotherapy was administered or not [27]
      • High Level Abstractions:
        • (adjuvant,tumor)
        • (adjuvant,colon,tumor)
        • (chemotherapy,risk,tumor)
        • (adjuvant,chemotherapy,colon,risk)
        • (colon,risk,tumor)
        • (chemotherapy,colon,postoperative)
        • (adjuvant,chemotherapy,tumor)
        • (colon,resection,risk)
        • (chemotherapy,colon,tumor)
        • (colon,metastasis,tumor)
        • (risk,tumor)
        • (adjuvant,chemotherapy,colon,tumor)
        • (resection,risk)
        • (colon,postoperative,resection)
        • Inferred entity relationships (216)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (risk,service) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • The benefits of adjuvant chemotherapy have been most clearly demonstrated in patients with stage III (node-positive) disease, who have an approximately 30 percent reduction in the risk of disease recurrence and a 22 to 32 percent reduction in mortality with modern chemotherapy.
      • High Level Abstractions:
        • (chemotherapy,colon,risk)
        • (adjuvant,iii,risk)
        • (adjuvant,colon,risk)
        • (adjuvant,chemotherapy,colon,risk)
        • (adjuvant,risk)
        • (adjuvant,colon,resected,risk)
        • (adjuvant,chemotherapy,risk)
        • (chemotherapy,colon,iii,risk)
        • (chemotherapy,iii,risk)
        • Inferred entity relationships (221)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (iii,resected,venous) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (risk,service) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • Five-year survival rates according to tumor stage at diagnosis for patients with colon cancer, derived from the population-based Surveillance, Epidemiology, and End Results (SEER) database and stratified according to the current 2010 American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) tumor, node, metastasis (TNM) staging classification, are illustrated in the figure (figure 2) [25].
        For individual patients, a postoperative nomogram has been developed that permits prediction of the risk of a colon cancer recurrence based upon clinicopathologic factors and whether adjuvant chemotherapy was administered or not [27].
      • High Level Abstractions:
        • (clinicopathologic,colon,tumor)
        • (clinicopathologic,colon,risk)
        • (chemotherapy,clinicopathologic,tumor)
        • (adjuvant,clinicopathologic,colon)
        • (chemotherapy,clinicopathologic,colon)
        • (adjuvant,chemotherapy,clinicopathologic,colon)
        • (chemotherapy,clinicopathologic,risk)
        • (adjuvant,resection)
        • (clinicopathologic,risk)
        • Inferred entity relationships (219)
        • (chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (clinicopathologic,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (clinicopathologic,colon,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (risk,service) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (clinicopathologic,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • (See "Adjuvant therapy for resected colon cancer in older adult patients", section on 'Oxaliplatin-based regimens'and "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Oxaliplatin-based therapy'.)
        The optimal duration of oxaliplatin-containing chemotherapy is evolving.
      • High Level Abstractions:
        • (chemotherapy,colon,iii,oxaliplatin-containing)
        • Inferred entity relationships (158)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • (See "Adjuvant therapy for resected stage III (node-positive) colon cancer".)
        Most treatments involve a combination of several chemotherapy drugs, which are given intravenously in a specific order on specific days.
      • High Level Abstractions:
        • (chemotherapy,colon,iii,intravenously)
        • Inferred entity relationships (158)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • Prognostic factors for outcome in patients with recurrent colon cancer were addressed in a large database series of 17,381 patients who were enrolled in 18 randomized phase III trials testing adjuvant chemotherapy for stage II or III colon cancer conducted mainly before 2000 in the era when treatment was mainly limited to fluorouracil (FU) [35].
      • High Level Abstractions:
        • (chemotherapy,colon,fluorouracil,iii)
        • (colon,fluorouracil,iii)
        • Inferred entity relationships (158)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • In an analysis of 3622 patients with colon cancer derived from two French digestive cancer registries, among men with no recurrence five years after the diagnosis of colon cancer, 1 in 12 (8.3 percent) developed a subsequent recurrence between years 5 and 10; the corresponding rate for women was 1 in 19 (5.3 percent) [31].
        A web-based tool is available to determine conditional survival expectancy based upon initial stage at diagnosis, ethnicity, age, gender, and histologic grade.
        Prognosis for patients with advanced (metastatic) colorectal cancer is highly variable and dependent on many factors, including age and performance status, site and number of metastases, molecular factors such as RAS or BRAF mutations and deficient DNA mismatch repair/microsatellite instability (MSI), eligibility for surgery or additional chemotherapy, and tumor location.
      • High Level Abstractions:
        • (colorectal,tumor)
        • (chemotherapy,colon,tumor)
        • (colorectal,metastases,tumor)
        • (chemotherapy,colorectal,tumor)
        • Inferred entity relationships (187)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (colorectal,msi) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • challenge (Read more)
      • (See "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Oxaliplatin-based therapy'.)
        Among patients with resected node-negative (stage II) disease, the benefits of chemotherapy are controversial, as is the relative benefit of an oxaliplatin-based as compared with a non-oxaliplatin-based regimen.
      • High Level Abstractions:
        • (cancers,colon,oxaliplatin-based)
        • (chemotherapy,colon,oxaliplatin-based)
        • Inferred entity relationships (193)
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,resection,tumor) [inferred]
        • (cancers,mmr) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (cancers,polyp) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (cancers,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (cancers,loss) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (cancers,resection,stalk) [inferred]

    • challenge (Read more)
      • It is generally preferable to obtain these scans prior to, rather than after, operation, as the scan results will occasionally change surgical planning.
        Contrast-enhanced magnetic resonance imaging (MRI) of the liver might identify more hepatic lesions than are visualized by CT and may be indicated to further define the extent of disease in patients who have suspected liver metastases on CT. (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Liver magnetic resonance imaging'.)
        Positron emission tomography (PET) scans do not appear to add significant information to CT scans for routine preoperative staging of colon cancer.
      • High Level Abstractions:
        • (colorectal,metastases,preoperative)
        • (metastases,preoperative,resection)
        • (colon,metastases,preoperative)
        • (colon,colorectal,preoperative,resection)
        • Inferred entity relationships (105)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (preoperative,resection) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • challenge (Read more)
      • It is generally preferable to obtain these scans prior to, rather than after, operation, as the scan results will occasionally change surgical planning.
        Contrast-enhanced magnetic resonance imaging (MRI) of the liver might identify more hepatic lesions than are visualized by CT and may be indicated to further define the extent of disease in patients who have suspected liver metastases on CT. (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Liver magnetic resonance imaging'.)
        Positron emission tomography (PET) scans do not appear to add significant information to CT scans for routine preoperative staging of colon cancer
      • High Level Abstractions:
        • (colon,colorectal,metastases,resection)
        • (lesions,metastases,resection)
        • (colon,colorectal,resection,visualized)
        • (colon,lesions,metastases)
        • (colon,colorectal,metastases)
        • (colorectal,metastases,visualized)
        • (colon,colorectal,resection,tomography)
        • (colon,metastases,resection)
        • (colon,metastases,visualized)
        • Inferred entity relationships (105)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (lesions,metastases,resection) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • challenge (Read more)
      • It is generally preferable to obtain these scans prior to, rather than after, operation, as the scan results will occasionally change surgical planning.
        Contrast-enhanced magnetic resonance imaging (MRI) of the liver might identify more hepatic lesions than are visualized by CT and may be indicated to further define the extent of disease in patients who have suspected liver metastases on CT. (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Liver magnetic resonance imaging'.)
        Positron emission tomography (PET) scans do not appear to add significant information to CT scans for routine preoperative staging of colon cancer. PET scan may be helpful for patients who are thought to be candidates for resection of isolated colorectal cancer liver and lung metastases, in whom the routine use of PET reduces the number of nontherapeutic laparotomies
      • High Level Abstractions:
        • (colon,preoperative)
        • (colon,preoperative,resection)
        • (preoperative,resection)
        • (candidates,colon,resection)
        • Inferred entity relationships (74)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (preoperative,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (candidates,colorectal,metastases) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (candidates,colorectal,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • Although fewer patients in the neoadjuvant chemotherapy group did not receive any chemotherapy (4 versus 27 percent), the majority of the patients who did not receive chemotherapy in the surgery upfront group did not receive it because they were perceived to have low-risk disease (16 percent), and only 11 percent either were too unwell for chemotherapy or refused it.
        Adjuvant chemotherapy. For patients who have undergone potentially curative resection of a colon cancer, the goal of postoperative (adjuvant) chemotherapy is to eradicate micrometastases, thereby reducing the likelihood of disease recurrence and increasing the cure rate
      • High Level Abstractions:
        • (colon,postoperative,resection)
        • Inferred entity relationships (70)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • (See "Pathology and prognostic determinants of colorectal cancer", section on 'Prognostic determinants'.)
        The most important indicator of outcome following resection of colon cancer is the pathologic stage at presentation [25,26]. Five-year survival rates according to tumor stage at diagnosis for patients with colon cancer, derived from the population-based Surveillance, Epidemiology, and End Results (SEER) database and stratified according to the current 2010 American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) tumor, node, metastasis (TNM) staging classification, are illustrated in the figure (figure 2) [25].
        For individual patients, a postoperative nomogram has been developed that permits prediction of the risk of a colon cancer recurrence based upon clinicopathologic factors and whether adjuvant chemotherapy was administered or not [27]
      • High Level Abstractions:
        • (pathologic,resection)
        • (colon,resection,tumor)
        • (resection,tumor)
        • Inferred entity relationships (70)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • In an analysis of 3622 patients with colon cancer derived from two French digestive cancer registries, among men with no recurrence five years after the diagnosis of colon cancer, 1 in 12 (8.3 percent) developed a subsequent recurrence between years 5 and 10; the corresponding rate for women was 1 in 19 (5.3 percent) [31].
        A web-based tool is available to determine conditional survival expectancy based upon initial stage at diagnosis, ethnicity, age, gender, and histologic grade.
        Prognosis for patients with advanced (metastatic) colorectal cancer is highly variable and dependent on many factors, including age and performance status, site and number of metastases, molecular factors such as RAS or BRAF mutations and deficient DNA mismatch repair/microsatellite instability (MSI), eligibility for surgery or additional chemotherapy, and tumor location
      • High Level Abstractions:
        • (colon,metastases,tumor)
        • (chemotherapy,colorectal,metastases)
        • (chemotherapy,colorectal,ras)
        • (chemotherapy,colon,metastases)
        • (chemotherapy,mismatch,tumor)
        • (colon,colorectal,tumor)
        • (colon,colorectal,metastases)
        • (chemotherapy,metastases,web-based)
        • (colon,mismatch,tumor)
        • (chemotherapy,metastases,registries)
        • (colon,metastases,web-based)
        • (chemotherapy,colon,colorectal)
        • (chemotherapy,metastases,tumor)
        • (colorectal,metastases,web-based)
        • (colon,colorectal,mismatch)
        • (chemotherapy,metastases,ras)
        • (chemotherapy,colorectal,web-based)
        • (chemotherapy,colorectal,registries)
        • Inferred entity relationships (187)
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (colorectal,loss) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colorectal,resectable) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (colorectal,msi) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (colorectal,tumor) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • challenge (Read more)
      • Clinical practice guidelines from ASCO and others recommend testing of all colorectal cancer for loss of mismatch repair protein expression (the underlying defect in Lynch syndrome) or microsatellite instability, the biologic footprint of mismatch repair protein deficiency [4-6]
      • High Level Abstractions:
        • (colorectal,loss)
        • (colon,colorectal,mismatch)
        • Inferred entity relationships (97)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • challenge (Read more)
      • Higher rates of diarrhea, nausea/vomiting, and myelosuppression are usually seen with bolus FU/LV regimens that do not require central venous access or an ambulatory infusion pump. (See "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Infusional versus bolus fluorouracil'.)
        In the experimental arm of this MOSAIC trial, the addition of oxaliplatin to infusional plus bolus FU/LV (the FOLFOX regimen) resulted in severe (grade 3 or worse) neutropenia (43 percent), diarrhea (11 percent), vomiting (6 percent), and stomatitis (3 percent) [18]
      • High Level Abstractions:
        • (bolus,colon,iii,resected)
        • (iii,resected,venous)
        • (colon,iii,resected,venous)
        • Inferred entity relationships (80)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (bolus,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (bolus,iii,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (bolus,colon,iii) [inferred]
        • (resected,risks) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (bolus,colon,resected) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • (See "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Infusional versus bolus fluorouracil'.)
        In the experimental arm of this MOSAIC trial, the addition of oxaliplatin to infusional plus bolus FU/LV (the FOLFOX regimen) resulted in severe (grade 3 or worse) neutropenia (43 percent), diarrhea (11 percent), vomiting (6 percent), and stomatitis (3 percent) [18]
      • High Level Abstractions:
        • (iii,neutropenia,resected)
        • (colon,iii,neutropenia)
        • (colon,iii,neutropenia,resected)
        • (colon,iii,infusional,resected)
        • (colon,iii,oxaliplatin,resected)
        • (colon,fluorouracil,iii)
        • (iii,infusional,resected)
        • (arm,colon,iii,resected)
        • (colon,neutropenia,resected)
        • (colon,iii,infusional)
        • (neutropenia,resected)
        • Inferred entity relationships (79)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (oxaliplatin,resected) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (arm,iii,resected) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (resected,risks) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (neutropenia,resected) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • (See "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Infusional versus bolus fluorouracil'.)
        In the experimental arm of this MOSAIC trial, the addition of oxaliplatin to infusional plus bolus FU/LV (the FOLFOX regimen) resulted in severe (grade 3 or worse) neutropenia (43 percent), diarrhea (11 percent), vomiting (6 percent), and stomatitis (3 percent) [18].
      • High Level Abstractions:
        • (colon,diarrhea,iii,resected)
        • (colon,iii,resected,vomiting)
        • (iii,resected,vomiting)
        • Inferred entity relationships (78)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (diarrhea,iii,resected) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (diarrhea,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (resected,risks) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • In patients with newly diagnosed invasive colon cancer, preoperative chest, abdomen, and pelvis CT scans can demonstrate regional tumor extension, regional lymphatic and distant metastases, and tumor-related complications (eg, obstruction, perforation, fistula formation), findings that may assist in selecting the therapeutic approach
      • High Level Abstractions:
        • (colon,metastases,tumor)
        • (colon,metastases,preoperative)
        • Inferred entity relationships (74)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (preoperative,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • (See "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Oxaliplatin-based therapy'.)
        Among patients with resected node-negative (stage II) disease, the benefits of chemotherapy are controversial, as is the relative benefit of an oxaliplatin-based as compared with a non-oxaliplatin-based regimen
      • High Level Abstractions:
        • (cancers,chemotherapy,colon)
        • Inferred entity relationships (194)
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (cancers,mmr) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (cancers,polyp) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (cancers,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (cancers,loss) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (cancers,resection,stalk) [inferred]

    • challenge (Read more)
      • Endoscopic resection is also a reasonable alternative to radical surgery for selected favorable-risk early stage colon cancers arising in a polyp. The presence of any of the following factors should prompt consideration of radical surgery, as they indicate a higher risk of residual cancer and/or nodal metastases (see "Surgical resection of primary colon cancer", section on 'Carcinoma in a polyp'):
        .Poorly differentiated histology
        .Lymphovascular invasion
        .Cancer at the resection or stalk margin
        .Invasion into the muscularis propria of the bowel wall (T2 lesion)
        .Invasive carcinoma arising in a sessile (flat) polyp with unfavorable features (eg, lower third submucosal penetration, lymphovascular invasion, poorly differentiated histology)
        Locally advanced primary lesions
      • High Level Abstractions:
        • (cancers,polyp)
        • (cancers,colon,polyp)
        • Inferred entity relationships (112)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colon,metastases,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (cancers,loss) [inferred]
        • (polyp,risk) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (cancers,colon,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (polyp,resection) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (cancers,resection,stalk) [inferred]

    • challenge (Read more)
      • On the other hand, given the small predicted loss of absolute disease-free survival benefit (absolute difference 0.9 percent at three years) and the significantly lower rates of oxaliplatin neuropathy seen in the IDEA collaboration analysis, adjuvant therapy can be limited to three months in patients with low-risk disease (T1-3N1), which makes up approximately 60 percent of all stage III colon cancers. These data are discussed in more detail separately. (See "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Oxaliplatin-based therapy'.)
        Among patients with resected node-negative (stage II) disease, the benefits of chemotherapy are controversial, as is the relative benefit of an oxaliplatin-based as compared with a non-oxaliplatin-based regimen
      • High Level Abstractions:
        • (cancers,colon,iii)
        • (cancers,colon,resected)
        • Inferred entity relationships (117)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colon,metastases,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (resected,risks) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (cancers,colon,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (cancers,resection,stalk) [inferred]

    • challenge (Read more)
      • (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Clinical staging evaluation'.)
        Radiographic imaging. In patients with newly diagnosed invasive colon cancer, preoperative chest, abdomen, and pelvis CT scans can demonstrate regional tumor extension, regional lymphatic and distant metastases, and tumor-related complications (eg, obstruction, perforation, fistula formation), findings that may assist in selecting the therapeutic approach
      • High Level Abstractions:
        • (colon,preoperative)
        • Inferred entity relationships (69)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (preoperative,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • challenge (Read more)
      • If adjuvant chemotherapy is chosen, most patients receive a fluoropyrimidine alone, unless they have a tumor with deficient mismatch repair status, in which case adjuvant fluoropyrimidines alone are ineffective
      • High Level Abstractions:
        • (adjuvant,chemotherapy,tumor)
        • (adjuvant,tumor)
        • Inferred entity relationships (143)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • challenge (Read more)
      • The range of treatment-related toxicity can be illustrated by the following clinical trial data:
        .In the X-ACT study, severe toxicities associated with six months of adjuvant treatment with oral capecitabine alone included hand-foot syndrome in 17 percent, diarrhea in 11 percent, nausea or vomiting in 3 percent, and stomatitis in 2 percent [17]
      • High Level Abstractions:
        • (adjuvant,treatment-related)
        • (adjuvant,chemotherapy,treatment-related)
        • (chemotherapy,treatment-related)
        • Inferred entity relationships (143)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • challenge (Read more)
      • While guidelines from the National Comprehensive Cancer Network (NCCN) [3] recommend six months of adjuvant chemotherapy after resection of colorectal cancer liver metastases, they do not address the utility of chemotherapy after resection of a local recurrence
      • High Level Abstractions:
        • (adjuvant,chemotherapy,resection)
        • (adjuvant,colorectal,metastases)
        • (chemotherapy,colorectal,resection)
        • (adjuvant,resection)
        • (colorectal,national_comprehensive_cancer_network,resection)
        • Inferred entity relationships (178)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (colorectal,loss) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (colorectal,msi) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (colorectal,risk) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (resection,risk) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colorectal,manifestations) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,resectable) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • challenge (Read more)
      • Treatment decisions must be individualized. Expert guidelines suggest that the risks and estimated benefits of adjuvant chemotherapy be discussed with patients who have resected node-negative colon cancer
      • High Level Abstractions:
        • (adjuvant,chemotherapy,risks)
        • Inferred entity relationships (142)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • challenge (Read more)
      • (See "Management of potentially resectable colorectal cancer liver metastases" and "Surgical resection of pulmonary metastases: Outcomes by histology" and "Surgical resection of pulmonary metastases: Benefits, indications, preoperative evaluation, and techniques".)
        Even patients who are not candidates for a curative resection can benefit from surgical palliation for symptoms of obstruction and bleeding from the primary tumor, although the overwhelming majority of patients without symptoms who initiate chemotherapy never require palliative surgery [24]
      • High Level Abstractions:
        • (chemotherapy,preoperative,resection)
        • (candidates,colorectal,resection)
        • (colorectal,tumor)
        • (colorectal,metastases,tumor)
        • (chemotherapy,colorectal,resectable)
        • (colorectal,metastases,preoperative)
        • (chemotherapy,pulmonary,tumor)
        • (colorectal,metastases,resectable)
        • (colorectal,metastases,pulmonary)
        • (chemotherapy,metastases,tumor)
        • (chemotherapy,colorectal,resection)
        • (chemotherapy,preoperative,tumor)
        • (chemotherapy,colorectal,tumor)
        • (chemotherapy,pulmonary,resection)
        • (chemotherapy,metastases,resectable)
        • (chemotherapy,colorectal,preoperative)
        • (colorectal,palliation,resection)
        • (metastases,pulmonary,resection)
        • (colorectal,resectable)
        • (resectable,resection)
        • (curative,metastases,resection)
        • (chemotherapy,curative,resection)
        • (chemotherapy,metastases,resection)
        • (colorectal,preoperative,resection)
        • (chemotherapy,resection,tumor)
        • (metastases,preoperative,resection)
        • (chemotherapy,metastases,pulmonary)
        • (chemotherapy,metastases,preoperative)
        • (chemotherapy,resectable,resection)
        • (colorectal,resectable,resection)
        • (histology,metastases,resection)
        • (preoperative,resection)
        • (chemotherapy,colorectal,pulmonary)
        • Inferred entity relationships (126)
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (candidates,colorectal,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (colorectal,msi) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (curative,metastases,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (candidates,colon,resection) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (resection,risk) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,resectable) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (resectable,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • challenge (Read more)
      • Preoperative chemotherapy was not associated with higher rates of perioperative complications, including anastomotic leak, but it was associated with lower rates of incomplete resection (5 versus 10 percent), and histologic downstaging of both pathologic tumor and nodal stage (including a 4 percent pathologic complete response rate [pathologic T0]).
      • High Level Abstractions:
        • (chemotherapy,resection,tumor)
        • (resection,tumor)
        • Inferred entity relationships (86)
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (resection,risk) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]

    • challenge (Read more)
      • Preoperative chemotherapy was not associated with higher rates of perioperative complications, including anastomotic leak, but it was associated with lower rates of incomplete resection (5 versus 10 percent), and histologic downstaging of both pathologic tumor and nodal stage (including a 4 percent pathologic complete response rate [pathologic T0])
      • High Level Abstractions:
        • (chemotherapy,pathologic,resection)
        • (pathologic,resection)
        • (chemotherapy,pathologic,tumor)
        • Inferred entity relationships (88)
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (resection,risk) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (pathologic,resection) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]

    • challenge (Read more)
      • While guidelines from the National Comprehensive Cancer Network (NCCN) [3] recommend six months of adjuvant chemotherapy after resection of colorectal cancer liver metastases, they do not address the utility of chemotherapy after resection of a local recurrence.
      • High Level Abstractions:
        • (chemotherapy,metastases,resection)
        • Inferred entity relationships (90)
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (resection,risk) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]

    • challenge (Read more)
      • If adjuvant chemotherapy is chosen, most patients receive a fluoropyrimidine alone, unless they have a tumor with deficient mismatch repair status, in which case adjuvant fluoropyrimidines alone are ineffective.
      • High Level Abstractions:
        • (chemotherapy,mismatch,tumor)
        • Inferred entity relationships (84)
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]

    • challenge (Read more)
      • In an analysis of 3622 patients with colon cancer derived from two French digestive cancer registries, among men with no recurrence five years after the diagnosis of colon cancer, 1 in 12 (8.3 percent) developed a subsequent recurrence between years 5 and 10; the corresponding rate for women was 1 in 19 (5.3 percent) [31].
        A web-based tool is available to determine conditional survival expectancy based upon initial stage at diagnosis, ethnicity, age, gender, and histologic grade.
        Prognosis for patients with advanced (metastatic) colorectal cancer is highly variable and dependent on many factors, including age and performance status, site and number of metastases, molecular factors such as RAS or BRAF mutations and deficient DNA mismatch repair/microsatellite instability (MSI), eligibility for surgery or additional chemotherapy, and tumor location. Nomograms for overall and progression-free survival based on several of these clinicopathologic factors have been developed that can assist in aiding prognostication and patient-physician communication; however, they do not include tumor location or MSI status and only apply to patients who are not candidates for or do not undergo metastasectomy [32].
        POSTTREATMENT SURVEILLANCE
        Following treatment for a stage II or III colon cancer, posttreatment surveillance usually consists of periodic history and physical examination, with serial assay of the serum concentrations of the tumor marker carcinoembryonic antigen (CEA), annual surveillance computed tomography (CT) scans, and colonoscopy to detect metachronous primaries
      • High Level Abstractions:
        • (chemotherapy,clinicopathologic,tumor)
        • Inferred entity relationships (87)
        • (chemotherapy,colon,risk) [inferred]
        • (clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (clinicopathologic,colon,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (clinicopathologic,colon,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]

    • challenge (Read more)
      • Management of potentially resectable hepatic metastases (including a discussion as to integration of systemic chemotherapy into the surgical paradigm) and resection of pulmonary metastases are discussed in detail separately. (See "Management of potentially resectable colorectal cancer liver metastases" and "Surgical resection of pulmonary metastases: Outcomes by histology" and "Surgical resection of pulmonary metastases: Benefits, indications, preoperative evaluation, and techniques".)
        Even patients who are not candidates for a curative resection can benefit from surgical palliation for symptoms of obstruction and bleeding from the primary tumor, although the overwhelming majority of patients without symptoms who initiate chemotherapy never require palliative surgery [24]
      • High Level Abstractions:
        • (colorectal,pulmonary,resection)
        • Inferred entity relationships (30)
        • (colorectal,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,tumor) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (resection,risk) [inferred]
        • (resection,tumor) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (colorectal,risk) [inferred]

    • challenge (Read more)
      • The decision must be individualized and is based in part on whether adjuvant therapy (particularly an oxaliplatin-containing regimen) was administered previously. (See "Management of potentially resectable colorectal cancer liver metastases", section on 'Systemic chemotherapy'.)
        SOCIETY GUIDELINE LINKS
        Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately
      • High Level Abstractions:
        • (adjuvant,colorectal,metastases)
        • (colorectal,metastases,resectable)
        • Inferred entity relationships (91)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colorectal,manifestations) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colorectal,resectable) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (resectable,resection) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (adjuvant,resected) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colorectal,risk) [inferred]

    • challenge (Read more)
      • (See "Colorectal cancer: Epidemiology, risk factors, and protective factors", section on 'Hereditary CRC syndromes'and "Clinical manifestations and diagnosis of familial adenomatous polyposis" and "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Clinical manifestations and diagnosis".)
        Lynch syndrome is more common than FAP and accounts for approximately 2 to 3 percent of all colonic adenocarcinomas
      • High Level Abstractions:
        • (manifestations,risk)
        • (nonpolyposis,risk)
        • (colorectal,nonpolyposis,syndromes)
        • (colorectal,nonpolyposis,polyposis)
        • (colorectal,risk)
        • (colorectal,nonpolyposis,risk)
        • (colorectal,manifestations,nonpolyposis)
        • (colorectal,manifestations)
        • Inferred entity relationships (33)
        • (manifestations,risk) [inferred]
        • (risk,tumor) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (nonpolyposis,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,tumor) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (risk,service) [inferred]
        • (colorectal,risk) [inferred]

    • challenge (Read more)
      • If there is methylation of the MLH1 promoter and no BRAF mutation, then a disease-causing genetic defect should be considered, as 5 to 10 percent of these patients may harbor a germline mutation [33,34].
        .On the other hand, loss of expression of MSH2 alone, MSH2 in combination with MSH6, or MSH6 alone is highly specific for a disease-causing germline defect, and referral for genetic testing (for the genes corresponding to the absent proteins) is appropriate. (See "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Clinical manifestations and diagnosis" and "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Cancer screening and management".)
        Extracolonic cancers are very common in Lynch syndrome, particularly endometrial carcinomas, which may occur in up to 60 percent of female mutation carriers in some families
      • High Level Abstractions:
        • (colorectal,manifestations,nonpolyposis)
        • Inferred entity relationships (30)
        • (manifestations,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (nonpolyposis,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,tumor) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (colorectal,risk) [inferred]

    • challenge (Read more)
      • (See "Neoadjuvant chemoradiotherapy, radiotherapy, and chemotherapy for rectal adenocarcinoma".)
        There is no consensus as to which patients with colon cancer, if any, are suitable for neoadjuvant therapy. In our view, patients with potentially resectable disease with negative margins should undergo resection, rather than upfront chemotherapy or chemoradiotherapy, if they are surgical candidates
      • High Level Abstractions:
        • (resectable,resection)
        • Inferred entity relationships (2)
        • (resection,risk) [inferred]
        • (resection,tumor) [inferred]

    • WIP (Read more)
      • Expert guidelines suggest that the risks and estimated benefits of adjuvant chemotherapy be discussed with patients who have resected node-negative colon cancer. Among the issues that need to be taken into consideration when assessing the risk of recurrence and estimated benefit from specific chemotherapy regimens are the presence of high-risk clinicopathologic features (fewer than 12 nodes in the surgical specimen, T4 stage (table 1), perforated/obstructed tumor, poorly differentiated histology, lymphovascular or perineural invasion), mismatch repair enzyme status, assessment of comorbidities and anticipated life expectancy, and given the relatively good prognosis of stage II disease, the potential risks associated with treatment
      • High Level Abstractions:
        • (adjuvant,chemotherapy,resected)
        • (adjuvant,chemotherapy,colon,resected)
        • (adjuvant,resected)
        • Inferred entity relationships (214)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • (See "Cutaneous side effects of conventional chemotherapy agents", section on 'Hand-foot syndrome (acral erythema)'and "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Oral fluoropyrimidines'.)
        .In the control arm of the MOSAIC trial, which demonstrated the benefit of oxaliplatin (FOLFOX) in stage III disease, severe (grade 3 or worse) toxicity with infusional and bolus FU plus LV consisted of diarrhea (7 percent), neutropenia (5 percent), nausea (2 percent), and stomatitis (2 percent) [18]
      • High Level Abstractions:
        • (colon,iii,infusional,resected)
        • (colon,iii,oxaliplatin,resected)
        • (bolus,resected)
        • (iii,infusional,resected)
        • (colon,iii,oxaliplatin)
        • (arm,iii,resected)
        • (colon,iii,infusional)
        • (bolus,colon,resected)
        • (bolus,colon,iii)
        • (chemotherapy,colon,fluoropyrimidines,iii)
        • (chemotherapy,colon,iii,resected)
        • (iii,oxaliplatin,resected)
        • (colon,oxaliplatin,resected)
        • (oxaliplatin,resected)
        • (arm,colon,iii,resected)
        • (chemotherapy,colon,iii,oxaliplatin)
        • (chemotherapy,colon,iii,infusional)
        • (bolus,colon,iii,resected)
        • (bolus,iii,resected)
        • Inferred entity relationships (169)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (resected,risk) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (arm,colon,iii,resected) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (bolus,iii,resected) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (bolus,colon,resected) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (oxaliplatin,resected) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (arm,iii,resected) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (bolus,resected) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (bolus,colon,iii,resected) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (bolus,colon,iii) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • Among the issues that need to be taken into consideration when assessing the risk of recurrence and estimated benefit from specific chemotherapy regimens are the presence of high-risk clinicopathologic features (fewer than 12 nodes in the surgical specimen, T4 stage (table 1), perforated/obstructed tumor, poorly differentiated histology, lymphovascular or perineural invasion), mismatch repair enzyme status, assessment of comorbidities and anticipated life expectancy, and given the relatively good prognosis of stage II disease, the potential risks associated with treatment.
      • High Level Abstractions:
        • (chemotherapy,colon,resected,risks)
        • (adjuvant,chemotherapy,risks)
        • Inferred entity relationships (213)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • Expert guidelines suggest that the risks and estimated benefits of adjuvant chemotherapy be discussed with patients who have resected node-negative colon cancer
      • High Level Abstractions:
        • (resected,risks)
        • (adjuvant,colon,risks)
        • (chemotherapy,resected,risks)
        • (chemotherapy,colon,resected,risks)
        • (adjuvant,colon,resected,risks)
        • (adjuvant,chemotherapy,colon,risks)
        • (colon,resected,risks)
        • Inferred entity relationships (214)
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • Among the issues that need to be taken into consideration when assessing the risk of recurrence and estimated benefit from specific chemotherapy regimens are the presence of high-risk clinicopathologic features (fewer than 12 nodes in the surgical specimen, T4 stage (table 1), perforated/obstructed tumor, poorly differentiated histology, lymphovascular or perineural invasion), mismatch repair enzyme status, assessment of comorbidities and anticipated life expectancy, and given the relatively good prognosis of stage II disease, the potential risks associated with treatment
      • High Level Abstractions:
        • (adjuvant,risk)
        • (clinicopathologic,colon,tumor)
        • (clinicopathologic,colon,risk)
        • (adjuvant,tumor)
        • (chemotherapy,colon,resected,tumor)
        • (chemotherapy,clinicopathologic,tumor)
        • (adjuvant,colon,tumor)
        • (chemotherapy,colon,risk)
        • (chemotherapy,mismatch,tumor)
        • (chemotherapy,risk,tumor)
        • (adjuvant,colon,risk)
        • (adjuvant,colon,resected,tumor)
        • (adjuvant,clinicopathologic,colon)
        • (chemotherapy,clinicopathologic,colon)
        • (chemotherapy,perineural,resected)
        • (adjuvant,chemotherapy,colon,risk)
        • (adjuvant,chemotherapy,clinicopathologic,colon)
        • (colon,mismatch,tumor)
        • (chemotherapy,resected,risk)
        • (adjuvant,colon,resected,risk)
        • (colon,resected,risk)
        • (colon,risk,tumor)
        • (resected,risk)
        • (adjuvant,colon,perineural,resected)
        • (adjuvant,chemotherapy,tumor)
        • (colon,lymphovascular,risk)
        • (chemotherapy,colon,resected,risk)
        • (chemotherapy,colon,tumor)
        • (adjuvant,chemotherapy,risk)
        • (colon,histology,risk)
        • (colon,nodes,tumor)
        • (chemotherapy,resected,tumor)
        • (chemotherapy,clinicopathologic,resected)
        • (risk,tumor)
        • (chemotherapy,clinicopathologic,risk)
        • (adjuvant,chemotherapy,colon,tumor)
        • (clinicopathologic,risk)
        • (chemotherapy,colon,perineural,resected)
        • (chemotherapy,clinicopathologic,colon,resected)
        • Inferred entity relationships (223)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (clinicopathologic,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (clinicopathologic,colon,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (lymphovascular,metastases,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (histology,metastases,resection) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (risk,service) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (clinicopathologic,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (lymphovascular,risk) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • (See "Adjuvant chemotherapy for resected stage II colon cancer", section on 'Web-based tools'.)
        In general, older adult patients gain as much benefit from adjuvant FU-based chemotherapy as do younger individuals, although it is used less often in older adults, and rates of treatment-related toxicity may be higher.
      • High Level Abstractions:
        • (chemotherapy,colon,treatment-related)
        • (adjuvant,chemotherapy,colon,treatment-related)
        • (chemotherapy,colon,resected,treatment-related)
        • (chemotherapy,treatment-related)
        • (adjuvant,treatment-related)
        • (adjuvant,colon,resected,treatment-related)
        • (adjuvant,colon,treatment-related)
        • (adjuvant,chemotherapy,treatment-related)
        • (chemotherapy,resected,treatment-related)
        • Inferred entity relationships (214)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • In data derived from the 20,800-patient ACCENT database of patients undergoing adjuvant chemotherapy for stage II or III colon cancer, recurrence rates after five years never exceeded 1.5 percent annually, and after eight years, they were 0.5 percent per year [29].
        As a result, conditional survival (eg, the survival probability after a given length of survival) improves dramatically after five years
      • High Level Abstractions:
        • (adjuvant,chemotherapy,colon,iii)
        • (adjuvant,colon,iii)
        • Inferred entity relationships (217)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (iii,resected,venous) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • While concurrently administered chemotherapy plus radiation therapy (RT) provides synergistic antitumor activity, it also increases treatment-related toxicity, which may be prohibitive if the radiation treatment volume includes a substantial amount of bowel.
        The utility of preoperative chemotherapy for patients with primary colon cancers was directly addressed in the phase III FOxTROT trial, in which 1052 patients with a computed tomography (CT) scan-predicted, T3-4N0-2, nonobstructed primary colon cancer who had no metastatic disease and who were fit for chemotherapy were randomly assigned to surgery upfront followed by six months of adjuvant oxaliplatin-based chemotherapy or to six weeks of preoperative oxaliplatin-based chemotherapy followed by surgery and then 18 additional weeks of chemotherapy [15]
      • High Level Abstractions:
        • (adjuvant,chemotherapy,colon,volume)
        • (chemotherapy,colon,treatment-related)
        • (cancers,colon,preoperative)
        • (cancers,oxaliplatin-based)
        • (adjuvant,oxaliplatin-based)
        • (adjuvant,chemotherapy,colon,treatment-related)
        • (cancers,chemotherapy)
        • (cancers,colon,oxaliplatin-based)
        • (chemotherapy,treatment-related)
        • (adjuvant,chemotherapy,colon,oxaliplatin-based)
        • (adjuvant,treatment-related)
        • (adjuvant,colon,preoperative)
        • (adjuvant,chemotherapy,oxaliplatin-based)
        • (adjuvant,colon,treatment-related)
        • (adjuvant,colon,oxaliplatin-based)
        • (adjuvant,chemotherapy,treatment-related)
        • (cancers,colon,nonobstructed)
        • (chemotherapy,colon,oxaliplatin-based)
        • (cancers,chemotherapy,colon)
        • (adjuvant,chemotherapy,colon,preoperative)
        • (colon,preoperative)
        • (adjuvant,chemotherapy,preoperative)
        • Inferred entity relationships (254)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (cancers,mmr) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (cancers,colon,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (cancers,polyp) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (preoperative,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (cancers,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (cancers,loss) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (cancers,resection,stalk) [inferred]

    • WIP (Read more)
      • (See "Cutaneous side effects of conventional chemotherapy agents", section on 'Hand-foot syndrome (acral erythema)'and "Adjuvant therapy for resected stage III (node-positive) colon cancer", section on 'Oral fluoropyrimidines'.)
        .In the control arm of the MOSAIC trial, which demonstrated the benefit of oxaliplatin (FOLFOX) in stage III disease, severe (grade 3 or worse) toxicity with infusional and bolus FU plus LV consisted of diarrhea (7 percent), neutropenia (5 percent), nausea (2 percent), and stomatitis (2 percent) [18].
      • High Level Abstractions:
        • (iii,neutropenia,resected)
        • (neutropenia,resected)
        • (colon,iii,neutropenia)
        • (colon,iii,neutropenia,resected)
        • (chemotherapy,colon,iii,neutropenia)
        • (diarrhea,resected)
        • (colon,diarrhea,resected)
        • (colon,diarrhea,iii,resected)
        • (colon,diarrhea,iii)
        • (colon,neutropenia,resected)
        • (diarrhea,iii,resected)
        • Inferred entity relationships (163)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (resected,risk) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (diarrhea,resected) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (diarrhea,iii,resected) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (neutropenia,resected) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • For patients who have undergone potentially curative resection of a colon cancer, the goal of postoperative (adjuvant) chemotherapy is to eradicate micrometastases, thereby reducing the likelihood of disease recurrence and increasing the cure rate
      • High Level Abstractions:
        • (chemotherapy,colon,postoperative)
        • (chemotherapy,postoperative,resection)
        • (chemotherapy,curative,resection)
        • (chemotherapy,colon,resection)
        • (adjuvant,iii,postoperative)
        • (adjuvant,iii,resection)
        • Inferred entity relationships (220)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (curative,metastases,resection) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (resection,tumor) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (iii,resected,venous) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • Patients who are appropriate for initial chemotherapy include those with locally unresectable colon cancer, those whose margins of resection are judged to be potentially compromised, or those who are medically inoperable.
      • High Level Abstractions:
        • (chemotherapy,colon,resection)
        • Inferred entity relationships (155)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • In our view, patients with potentially resectable disease with negative margins should undergo resection, rather than upfront chemotherapy or chemoradiotherapy, if they are surgical candidates. Patients who are appropriate for initial chemotherapy include those with locally unresectable colon cancer, those whose margins of resection are judged to be potentially compromised, or those who are medically inoperable
      • High Level Abstractions:
        • (chemoradiotherapy,colon,resection)
        • (chemotherapy,colon,resection)
        • (chemoradiotherapy,resection)
        • (chemotherapy,colon,unresectable)
        • (chemoradiotherapy,chemotherapy)
        • (chemoradiotherapy,chemotherapy,resection)
        • (candidates,colon,resection)
        • Inferred entity relationships (162)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (chemoradiotherapy,colon,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (candidates,colorectal,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemoradiotherapy,chemotherapy,resection) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemoradiotherapy,chemotherapy) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (candidates,colorectal,resection) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemoradiotherapy,resection) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • (See 'Neoadjuvant chemoradiotherapy or chemotherapy'above.)
        .For patients who have undergone potentially curative resection of a colon cancer, postoperative (adjuvant) chemotherapy eradicates micrometastases, reduces the likelihood of disease recurrence, and increases cure rates
      • High Level Abstractions:
        • (chemotherapy,colon,postoperative)
        • (chemoradiotherapy,colon,resection)
        • (chemotherapy,colon,resection)
        • (chemotherapy,curative,resection)
        • Inferred entity relationships (160)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (curative,metastases,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemoradiotherapy,chemotherapy,resection) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemoradiotherapy,chemotherapy) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemoradiotherapy,resection) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • Patients who are appropriate for initial chemotherapy include those with locally unresectable colon cancer, those whose margins of resection are judged to be potentially compromised, or those who are medically inoperable
      • High Level Abstractions:
        • (colon,resection,unresectable)
        • (chemotherapy,colon,unresectable)
        • Inferred entity relationships (155)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • PET scan may be helpful for patients who are thought to be candidates for resection of isolated colorectal cancer liver and lung metastases, in whom the routine use of PET reduces the number of nontherapeutic laparotomies.
      • High Level Abstractions:
        • (colon,colorectal,metastases,resection)
        • (colon,colorectal,nontherapeutic,resection)
        • (colorectal,metastases,resection)
        • Inferred entity relationships (104)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • The rationale for and evidence supporting these guidelines are discussed elsewhere, as are issues that arise in long-term survivors of colon cancer. (See "Surveillance after colorectal cancer resection" and "Approach to the long-term survivor of colorectal cancer".)
        GENETIC ISSUES
        Although most colorectal cancers are sporadic, specific genetic disorders have been identified, most of which are autosomal dominant, that are associated with a very high risk of developing the disease
      • High Level Abstractions:
        • (colon,colorectal,long-term)
        • (colorectal,long-term,resection)
        • (colon,colorectal,long-term,resection)
        • Inferred entity relationships (101)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (long-term,service) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • The presence of any of the following factors should prompt consideration of radical surgery, as they indicate a higher risk of residual cancer and/or nodal metastases (see "Surgical resection of primary colon cancer", section on 'Carcinoma in a polyp'):
        .Poorly differentiated histology
        .Lymphovascular invasion
        .Cancer at the resection or stalk margin
        .Invasion into the muscularis propria of the bowel wall (T2 lesion)
        .Invasive carcinoma arising in a sessile (flat) polyp with unfavorable features (eg, lower third submucosal penetration, lymphovascular invasion, poorly differentiated histology)
        Locally advanced primary lesions
      • High Level Abstractions:
        • (cancers,polyp,resection)
        • (colon,histology,metastases)
        • (cancers,resection,stalk)
        • (colon,resection,risk)
        • (metastases,polyp,resection)
        • (colon,histology,risk)
        • (cancers,carcinoma,resection)
        • (histology,risk)
        • (cancers,resection,submucosal)
        • (polyp,risk)
        • (cancers,risk)
        • (colon,metastases,polyp)
        • (cancers,colon,resection)
        • (polyp,resection)
        • (cancers,colon,histology)
        • (colon,polyp,risk)
        • (resection,risk)
        • (colon,metastases,resection)
        • (cancers,histology,resection)
        • (histology,metastases,resection)
        • (cancers,carcinoma)
        • (colon,risk,submucosal)
        • Inferred entity relationships (122)
        • (colon,colorectal,long-term,resection) [inferred]
        • (risk,tumor) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colon,metastases,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (cancers,loss) [inferred]
        • (polyp,risk) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,markers,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (histology,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (cancers,colon,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (histology,metastases,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (polyp,resection) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (risk,service) [inferred]
        • (cancers,resection,stalk) [inferred]

    • WIP (Read more)
      • (See "Surgical resection of primary colon cancer".)
        Restoration of bowel continuity using a primary anastomosis can be accomplished in most patients undergoing an uncomplicated colectomy.
      • High Level Abstractions:
        • (colectomy,colon,resection)
        • Inferred entity relationships (71)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • (See "Management of potentially resectable colorectal cancer liver metastases", section on 'Utility of PET scans'.)
        Tumor markers.
      • High Level Abstractions:
        • (colon,colorectal,metastases)
        • (colon,colorectal,markers)
        • Inferred entity relationships (102)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • (See 'Colonoscopy'above.)
        .A family history of colorectal and other extracolonic cancers should be sought prior to therapy, as an inherited predisposition to colon cancer may alter the surgical approach, prompting consideration of subtotal or total colectomy in high-risk individuals
      • High Level Abstractions:
        • (cancers,colorectal,predisposition)
        • (cancers,colon,colorectal)
        • Inferred entity relationships (139)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colon,metastases,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (cancers,loss) [inferred]
        • (colorectal,tumor) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (colorectal,risk) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (cancers,colon,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (cancers,resection,stalk) [inferred]

    • WIP (Read more)
      • (You can also locate patient education articles on a variety of subjects by searching on "patient info" and the keyword(s) of interest.)
        .Basics topics (see "Patient education: Colon and rectal cancer (The Basics)" and "Patient education: Colectomy (The Basics)")
        .Beyond the Basics topics (see "Patient education: Colon and rectal cancer (Beyond the Basics)" and "Patient education: Colorectal cancer treatment; metastatic cancer (Beyond the diagnosis of colon cancer is usually made by colonoscopy
      • High Level Abstractions:
        • (colon,rectal)
        • (colon,colorectal,rectal)
        • Inferred entity relationships (99)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (rectal,resected) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • (See 'Genetic issues'below and "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Clinical manifestations and diagnosis" and "MUTYH-associated polyposis", section on 'Colonic manifestations'.)
        However, use of family history alone is not sufficient to identify most patients with a hereditary colon cancer syndrome, particularly Lynch syndrome
      • High Level Abstractions:
        • (colorectal,nonpolyposis,polyposis)
        • (colon,colorectal,nonpolyposis)
        • (colorectal,manifestations,nonpolyposis)
        • (colorectal,manifestations)
        • (colon,colorectal,manifestations)
        • Inferred entity relationships (100)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (nonpolyposis,risk) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (manifestations,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • (See "Systemic chemotherapy for nonoperable metastatic colorectal cancer: Treatment recommendations".)
        Until more recently, most of the data addressing the benefit of neoadjuvant therapies in patients with colon primaries have been limited to isolated case reports and two small case series [9-14]
      • High Level Abstractions:
        • (colon,colorectal,metastatic)
        • Inferred entity relationships (97)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • (You can also locate patient education articles on a variety of subjects by searching on "patient info" and the keyword(s) of interest.)
        .Basics topics (see "Patient education: Colon and rectal cancer (The Basics)" and "Patient education: Colectomy (The Basics)")
        .Beyond the Basics topics (see "Patient education: Colon and rectal cancer (Beyond the Basics)" and "Patient education: Colorectal cancer treatment; metastatic cancer (Beyond the diagnosis of colon cancer is usually made by colonoscopy.
      • High Level Abstractions:
        • (colon,colorectal,metastatic)
        • Inferred entity relationships (97)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Tumor markers'.)
        Colonoscopy.
      • High Level Abstractions:
        • (colon,colorectal,markers)
        • Inferred entity relationships (97)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • Postoperative RT is not usually considered a routine component of care for completely resected colon cancer. This is in contrast to patients with rectal cancer, in whom effective adjuvant therapy for both transmural and node-positive disease includes RT. Local recurrence is more frequent with rectal cancer due to the local anatomy and the difficulty in obtaining adequate resection margins
      • High Level Abstractions:
        • (adjuvant,colon,rectal)
        • (adjuvant,colon,resected,transmural)
        • (colon,rectal)
        • (rectal,resected)
        • (adjuvant,colon,rectal,resected)
        • (colon,rectal,resected)
        • (adjuvant,resected)
        • Inferred entity relationships (130)
        • (colon,colorectal,long-term,resection) [inferred]
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (rectal,resected) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (adjuvant,resected) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • WIP (Read more)
      • On the other hand, given the small predicted loss of absolute disease-free survival benefit (absolute difference 0.9 percent at three years) and the significantly lower rates of oxaliplatin neuropathy seen in the IDEA collaboration analysis, adjuvant therapy can be limited to three months in patients with low-risk disease (T1-3N1), which makes up approximately 60 percent of all stage III colon cancers.
      • High Level Abstractions:
        • (adjuvant,colon,iii,resected)
        • Inferred entity relationships (133)
        • (colon,colorectal,long-term,resection) [inferred]
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (adjuvant,resected) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • WIP (Read more)
      • On the other hand, given the small predicted loss of absolute disease-free survival benefit (absolute difference 0.9 percent at three years) and the significantly lower rates of oxaliplatin neuropathy seen in the IDEA collaboration analysis, adjuvant therapy can be limited to three months in patients with low-risk disease (T1-3N1), which makes up approximately 60 percent of all stage III colon cancers
      • High Level Abstractions:
        • (colon,iii,oxaliplatin,resected)
        • (colon,iii,oxaliplatin)
        • (adjuvant,disease-free,iii)
        • (adjuvant,iii,oxaliplatin)
        • (adjuvant,neuropathy)
        • (adjuvant,colon,iii)
        • (iii,oxaliplatin,resected)
        • (colon,oxaliplatin,resected)
        • (oxaliplatin,resected)
        • (adjuvant,oxaliplatin)
        • (adjuvant,iii,neuropathy)
        • Inferred entity relationships (135)
        • (colon,colorectal,long-term,resection) [inferred]
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (colon,metastases,resection) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (resected,risks) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (oxaliplatin,resected) [inferred]
        • (colon,resected,risk) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,rectal,resected) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (adjuvant,resected) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • WIP (Read more)
      • Higher rates of diarrhea, nausea/vomiting, and myelosuppression are usually seen with bolus FU/LV regimens that do not require central venous access or an ambulatory infusion pump
      • High Level Abstractions:
        • (colon,diarrhea,iii,resected)
        • Inferred entity relationships (77)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (diarrhea,iii,resected) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (diarrhea,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (resected,risks) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • The benefits of adjuvant chemotherapy have been most clearly demonstrated in patients with stage III (node-positive) disease, who have an approximately 30 percent reduction in the risk of disease recurrence and a 22 to 32 percent reduction in mortality with modern chemotherapy. (See "Adjuvant therapy for resected stage III (node-positive) colon cancer".)
        Most treatments involve a combination of several chemotherapy drugs, which are given intravenously in a specific order on specific days
      • High Level Abstractions:
        • (colon,resected,risk)
        • (resected,risk)
        • Inferred entity relationships (72)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (risk,tumor) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (resected,risks) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (risk,service) [inferred]

    • WIP (Read more)
      • Specific issues surrounding the use of adjuvant chemotherapy in older adult patients and the utility of a comprehensive geriatric assessment in formulating an appropriate, individualized treatment plan for the older adult patient are discussed elsewhere
      • High Level Abstractions:
        • (colon,geriatric,resected)
        • (geriatric,resected)
        • Inferred entity relationships (71)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (resected,risks) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (geriatric,resected) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • (See "Adjuvant therapy for resected colon cancer in older adult patients" and "Comprehensive geriatric assessment".)
        Side effects.
      • High Level Abstractions:
        • (colon,geriatric,resected)
        • Inferred entity relationships (71)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (resected,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (resected,risks) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (geriatric,resected) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • Nomograms for overall and progression-free survival based on several of these clinicopathologic factors have been developed that can assist in aiding prognostication and patient-physician communication; however, they do not include tumor location or MSI status and only apply to patients who are not candidates for or do not undergo metastasectomy [32].
        POSTTREATMENT SURVEILLANCE
        Following treatment for a stage II or III colon cancer, posttreatment surveillance usually consists of periodic history and physical examination, with serial assay of the serum concentrations of the tumor marker carcinoembryonic antigen (CEA), annual surveillance computed tomography (CT) scans, and colonoscopy to detect metachronous primaries
      • High Level Abstractions:
        • (clinicopathologic,colon,tumor)
        • (colon,iii,posttreatment)
        • (colon,iii,tumor)
        • (chemotherapy,iii,posttreatment)
        • (colon,posttreatment,tumor)
        • (chemotherapy,iii,progression-free)
        • (chemotherapy,iii,tumor)
        • (chemotherapy,iii,prognostication)
        • Inferred entity relationships (161)
        • (colon,colorectal,long-term,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (colon,iii,infusional) [inferred]
        • (clinicopathologic,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (colon,preoperative) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,metastases,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colon,iii,risk) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (clinicopathologic,colon,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colon,resected,risk) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,iii,tumor) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • (See 'Metastatic disease'above.)
        .The most important indicator of outcome following resection of colon cancer is pathologic stage (figure 2) (see 'Prognosis'above). Following treatment for a stage II or III colon cancer, posttreatment surveillance usually consists of periodic history and physical examination and assay of the serum CEA, annual surveillance CT scans, and periodic colonoscopy
      • High Level Abstractions:
        • (pathologic,resection)
        • (colon,iii,posttreatment)
        • Inferred entity relationships (75)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (iii,resected,venous) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (iii,infusional,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (resection,tumor) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • (See "Management of potentially resectable colorectal cancer liver metastases", section on 'Utility of PET scans'.)
        Tumor markers. A variety of tumor markers have been associated with colon cancer, especially carcinoembryonic antigen (CEA)
      • High Level Abstractions:
        • (colon,metastases,tumor)
        • (colon,markers,metastases)
        • (colon,markers,tumor)
        • Inferred entity relationships (73)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • (See "Management of potentially resectable colorectal cancer liver metastases", section on 'Utility of PET scans'.)
        Tumor markers
      • High Level Abstractions:
        • (colorectal,metastases,resectable)
        • (colorectal,resectable)
        • (colon,colorectal,tumor)
        • Inferred entity relationships (102)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (resectable,resection) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • The stage of a colon cancer has three components, primary tumor (T), status of the regional nodes (N), and distant metastasis (M), which together are combined to form stage groupings from I to IV. Stage groupings permit the stratification of prognosis, which is useful for the selection of treatment
      • High Level Abstractions:
        • (colon,metastasis,tumor)
        • (colon,nodes,tumor)
        • (colon,groupings,tumor)
        • Inferred entity relationships (69)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (colon,rectal) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,resection) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,markers,tumor) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (colon,nodes,tumor) [inferred]

    • WIP (Read more)
      • The presence of any of the following factors should prompt consideration of radical surgery, as they indicate a higher risk of residual cancer and/or nodal metastases (see "Surgical resection of primary colon cancer", section on 'Carcinoma in a polyp'):
        .Poorly differentiated histology
        .Lymphovascular invasion
        .Cancer at the resection or stalk margin
        .Invasion into the muscularis propria of the bowel wall (T2 lesion)
        .Invasive carcinoma arising in a sessile (flat) polyp with unfavorable features (eg, lower third submucosal penetration, lymphovascular invasion, poorly differentiated histology)
        Locally advanced primary lesions.
      • High Level Abstractions:
        • (colon,lymphovascular,risk)
        • (cancers,lymphovascular,resection)
        • (colon,lesions,metastases)
        • (lymphovascular,risk)
        • (colon,lymphovascular,metastases)
        • (cancers,colon,lymphovascular)
        • (lymphovascular,metastases,resection)
        • Inferred entity relationships (121)
        • (colon,colorectal,long-term,resection) [inferred]
        • (risk,tumor) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colon,metastases,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (lesions,metastases,resection) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (resection,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (colon,resected,risk) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (cancers,colon,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (lymphovascular,metastases,resection) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (lymphovascular,risk) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (risk,service) [inferred]
        • (cancers,resection,stalk) [inferred]

    • WIP (Read more)
      • (See 'Colonoscopy'above.)
        .A family history of colorectal and other extracolonic cancers should be sought prior to therapy, as an inherited predisposition to colon cancer may alter the surgical approach, prompting consideration of subtotal or total colectomy in high-risk individuals.
      • High Level Abstractions:
        • (cancers,colectomy,resection)
        • (cancers,resection,subtotal)
        • (cancers,colorectal,individuals)
        • (cancers,colectomy,colon)
        • Inferred entity relationships (144)
        • (colon,colorectal,long-term,resection) [inferred]
        • (colon,iii,infusional) [inferred]
        • (colon,preoperative) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (colon,colorectal,nontherapeutic,resection) [inferred]
        • (colon,colorectal,rectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colon,lymphovascular,metastases) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (colon,risk,tumor) [inferred]
        • (colon,iii,neutropenia) [inferred]
        • (cancers,msi) [inferred]
        • (colon,colorectal,medical_oncology,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (colon,diarrhea,resected) [inferred]
        • (colon,colorectal,metastases,resection) [inferred]
        • (colon,colorectal,long-term) [inferred]
        • (colon,iii,posttreatment) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colon,metastases,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (colon,colorectal,markers) [inferred]
        • (colon,resection,risk) [inferred]
        • (colon,iii,risk) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colon,groupings,tumor) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (colon,colorectal,pelvic,resection) [inferred]
        • (colon,neutropenia,resected) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (cancers,loss) [inferred]
        • (colorectal,tumor) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (resection,tumor) [inferred]
        • (colon,colorectal,nonpolyposis) [inferred]
        • (colon,fluorouracil,iii) [inferred]
        • (colon,markers,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colon,risk,submucosal) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colectomy,colon,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colon,iii,resected,venous) [inferred]
        • (colon,resection,tumor) [inferred]
        • (colon,lymphovascular,risk) [inferred]
        • (colon,polyp,risk) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (colorectal,risk) [inferred]
        • (cancers,colon,histology) [inferred]
        • (colon,mismatch,tumor) [inferred]
        • (colon,resected,risks) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (colon,colorectal,preoperative) [inferred]
        • (colon,lesions,metastases) [inferred]
        • (colon,resection,unresectable) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colon,resected,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colon,rectal,resected) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colon,histology,risk) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (individuals,security) [inferred]
        • (colon,diarrhea,iii,resected) [inferred]
        • (colon,iii,infusional,resected) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (colon,histology,metastases) [inferred]
        • (colon,oxaliplatin,resected) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (resection,risk) [inferred]
        • (colon,metastases,preoperative) [inferred]
        • (colon,iii,oxaliplatin) [inferred]
        • (colon,colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (colon,metastasis,tumor) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (colon,iii,neutropenia,resected) [inferred]
        • (cancers,colon,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colon,metastases,polyp) [inferred]
        • (colon,rectal) [inferred]
        • (individuals,monetary,policy) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colon,colorectal,mismatch) [inferred]
        • (colon,colorectal,metastases) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (colon,colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colon,markers,metastases) [inferred]
        • (colon,metastases,tumor) [inferred]
        • (colorectal,resectable) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colon,colorectal,metastatic) [inferred]
        • (colon,iii,tumor) [inferred]
        • (colon,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colon,iii,oxaliplatin,resected) [inferred]
        • (colon,preoperative,resection) [inferred]
        • (colon,posttreatment,tumor) [inferred]
        • (colon,colorectal,manifestations) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colon,colorectal,resection,visualized) [inferred]
        • (colon,colorectal,tumor) [inferred]
        • (colon,diarrhea,iii) [inferred]
        • (colon,metastases,visualized) [inferred]
        • (colon,colorectal,resection,tomography) [inferred]
        • (colon,postoperative,resection) [inferred]
        • (colon,geriatric,resected) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colon,colorectal,preoperative,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colon,iii,resected,vomiting) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colon,nodes,tumor) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (cancers,resection,stalk) [inferred]

    • WIP (Read more)
      • Survival was significantly better in patients with initial stage II rather than stage III tumors (median 18 versus 13 months), in those with a longer disease-free interval, and in those who did not receive FU-based adjuvant chemotherapy following resection of the primary tumor.
        Although there are no prospective trials to guide therapy, the management of these patients is typically multidisciplinary and may include chemotherapy, chemoradiotherapy, or intraoperative radiation therapy in addition to surgery
      • High Level Abstractions:
        • (adjuvant,chemotherapy,tumor)
        • (adjuvant,iii,tumor)
        • (adjuvant,disease-free,iii)
        • (adjuvant,chemotherapy,iii)
        • (adjuvant,resection)
        • (adjuvant,iii,tumors)
        • (chemotherapy,iii,tumors)
        • (chemotherapy,iii,resection)
        • (chemotherapy,resection,tumor)
        • (adjuvant,iii,multidisciplinary)
        • (chemotherapy,iii,tumor)
        • (resection,tumor)
        • (adjuvant,iii,resection)
        • (adjuvant,chemotherapy,resection)
        • Inferred entity relationships (150)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (iii,resected,venous) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (resection,risk) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (iii,infusional,resected) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • WIP (Read more)
      • It is one of two prognostic tools approved for use in patients with colon cancer by the AJCC, meeting all quality criteria [28].
        Most of the available prognostic estimates use five-year survival as the endpoint given that most recurrences develop within this time frame
      • High Level Abstractions:
        • (adjuvant,chemotherapy,prognostic)
        • (adjuvant,prognostic)
        • (chemotherapy,prognostic)
        • Inferred entity relationships (143)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (adjuvant,resected) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • WIP (Read more)
      • (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Metastatic disease'.)
        Although major advances in systemic chemotherapy have expanded the therapeutic options for these patients and improved median survival from less than one year in the single-agent fluoropyrimidine era to more than 30 months, fewer than 20 percent [23] of those treated with chemotherapy alone are still alive at five years, and only a few are free of disease, unless resection or ablation of metastases has been performed.
      • High Level Abstractions:
        • (chemotherapy,colorectal,metastases)
        • (chemotherapy,metastases,resection)
        • (colorectal,metastases,resection)
        • Inferred entity relationships (120)
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (colorectal,msi) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (resection,risk) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,resectable) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Metastatic disease'.)
        Although major advances in systemic chemotherapy have expanded the therapeutic options for these patients and improved median survival from less than one year in the single-agent fluoropyrimidine era to more than 30 months, fewer than 20 percent [23] of those treated with chemotherapy alone are still alive at five years, and only a few are free of disease, unless resection or ablation of metastases has been performed
      • High Level Abstractions:
        • (chemotherapy,colorectal,single-agent)
        • (chemotherapy,colorectal,resection)
        • (chemotherapy,metastases,single-agent)
        • Inferred entity relationships (120)
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,loss) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (colorectal,msi) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,tumor) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (resection,risk) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,resectable) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (metastases,polyp,resection) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,pulmonary,resection) [inferred]

    • WIP (Read more)
      • Survival was significantly better in patients with initial stage II rather than stage III tumors (median 18 versus 13 months), in those with a longer disease-free interval, and in those who did not receive FU-based adjuvant chemotherapy following resection of the primary tumor.
        Although there are no prospective trials to guide therapy, the management of these patients is typically multidisciplinary and may include chemotherapy, chemoradiotherapy, or intraoperative radiation therapy in addition to surgery.
      • High Level Abstractions:
        • (chemoradiotherapy,chemotherapy)
        • (chemoradiotherapy,chemotherapy,resection)
        • (chemoradiotherapy,resection)
        • Inferred entity relationships (91)
        • (chemoradiotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemoradiotherapy,chemotherapy) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (resection,risk) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemoradiotherapy,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (resection,tumor) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemoradiotherapy,chemotherapy,resection) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]

    • WIP (Read more)
      • Nomograms for overall and progression-free survival based on several of these clinicopathologic factors have been developed that can assist in aiding prognostication and patient-physician communication; however, they do not include tumor location or MSI status and only apply to patients who are not candidates for or do not undergo metastasectomy [32].
        POSTTREATMENT SURVEILLANCE
        Following treatment for a stage II or III colon cancer, posttreatment surveillance usually consists of periodic history and physical examination, with serial assay of the serum concentrations of the tumor marker carcinoembryonic antigen (CEA), annual surveillance computed tomography (CT) scans, and colonoscopy to detect metachronous primaries.
      • High Level Abstractions:
        • (chemotherapy,iii,tomography)
        • Inferred entity relationships (89)
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (iii,resected,venous) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (iii,neutropenia,resected) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (iii,oxaliplatin,resected) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (iii,infusional,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (iii,resected,vomiting) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]

    • WIP (Read more)
      • (See 'Adjuvant chemotherapy'above.)
        .Chemotherapy carries a risk of significant toxicities, including mucositis, emesis, diarrhea, febrile neutropenia, fatigue, hair loss, hand-foot syndrome, and cardiotoxicity
      • High Level Abstractions:
        • (chemotherapy,mucositis,risk)
        • (chemotherapy,risk,toxicities)
        • Inferred entity relationships (87)
        • (chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (risk,service) [inferred]

    • WIP (Read more)
      • Chemotherapy carries a risk of significant toxicities, including mucositis, emesis, diarrhea, febrile neutropenia, fatigue, hair loss, hand-foot syndrome (a condition in which there is soreness, redness, and peeling of the skin of the palms and soles of the feet), and cardiotoxicity
      • High Level Abstractions:
        • (chemotherapy,neutropenia,risk)
        • (chemotherapy,loss,risk)
        • (chemotherapy,hand-foot,risk)
        • Inferred entity relationships (88)
        • (chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (neutropenia,resected) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (risk,service) [inferred]

    • WIP (Read more)
      • (See 'Adjuvant chemotherapy'above.)
        .Chemotherapy carries a risk of significant toxicities, including mucositis, emesis, diarrhea, febrile neutropenia, fatigue, hair loss, hand-foot syndrome, and cardiotoxicity.
      • High Level Abstractions:
        • (chemotherapy,neutropenia,risk)
        • (chemotherapy,loss,risk)
        • (chemotherapy,emesis,risk)
        • (chemotherapy,hand-foot,risk)
        • (neutropenia,resected)
        • (chemotherapy,febrile,risk)
        • (diarrhea,resected)
        • Inferred entity relationships (91)
        • (chemotherapy,colon,risk) [inferred]
        • (risk,tumor) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (resected,risk) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (resected,risks) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (diarrhea,iii,resected) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (neutropenia,resected) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (risk,service) [inferred]

    • WIP (Read more)
      • (See "Surgical resection of primary colon cancer", section on 'Locally advanced cancer'.)
        Neoadjuvant chemoradiotherapy or chemotherapy. Neoadjuvant (preoperative) chemoradiotherapy with or without chemotherapy, rather than initial surgery, is a common approach for locally advanced rectal cancer that is supported by data from randomized trials
      • High Level Abstractions:
        • (chemoradiotherapy,chemotherapy)
        • Inferred entity relationships (88)
        • (chemoradiotherapy,colon,resection) [inferred]
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,treatment-related) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemoradiotherapy,resection) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemoradiotherapy,chemotherapy,resection) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]

    • WIP (Read more)
      • In most modern trials, rates of treatment-related death range from 0.5 to 1 percent. (See "Cutaneous side effects of conventional chemotherapy agents", section on 'Hand-foot syndrome (acral erythema)'and "Overview of neurologic complications of platinum-based chemotherapy", section on 'Cumulative sensory neuropathy'and "Cardiotoxicity of non-anthracycline cancer chemotherapy agents", section on 'Fluorouracil'.)
        The most commonly used oxaliplatin-based regimens are FOLFOX and CAPOX. FOLFOX requires a central venous access catheter and the use of an ambulatory infusion pump
      • High Level Abstractions:
        • (chemotherapy,treatment-related)
        • Inferred entity relationships (84)
        • (chemotherapy,colon,risk) [inferred]
        • (chemotherapy,colon,treatment-related) [inferred]
        • (chemotherapy,pulmonary,tumor) [inferred]
        • (chemotherapy,clinicopathologic,resected) [inferred]
        • (chemotherapy,metastases,pulmonary) [inferred]
        • (chemotherapy,metastases,ras) [inferred]
        • (chemotherapy,colon,fluoropyrimidines,iii) [inferred]
        • (chemotherapy,metastases,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin) [inferred]
        • (chemotherapy,colorectal,resection) [inferred]
        • (chemotherapy,colon,colorectal) [inferred]
        • (chemotherapy,clinicopathologic,tumor) [inferred]
        • (chemotherapy,mucositis,risk) [inferred]
        • (chemotherapy,risk,tumor) [inferred]
        • (chemotherapy,postoperative,resection) [inferred]
        • (chemotherapy,metastases,single-agent) [inferred]
        • (chemotherapy,colon,resected,risk) [inferred]
        • (chemotherapy,colorectal,web-based) [inferred]
        • (chemotherapy,colon,iii,oxaliplatin-containing) [inferred]
        • (chemotherapy,colorectal,single-agent) [inferred]
        • (chemotherapy,colorectal,metastases) [inferred]
        • (chemotherapy,risk,toxicities) [inferred]
        • (chemotherapy,metastases,preoperative) [inferred]
        • (chemotherapy,colon,iii,resected) [inferred]
        • (chemotherapy,curative,resection) [inferred]
        • (chemotherapy,metastases,resection) [inferred]
        • (chemotherapy,colorectal,ras) [inferred]
        • (chemotherapy,emesis,risk) [inferred]
        • (chemotherapy,febrile,risk) [inferred]
        • (chemotherapy,colorectal,resectable) [inferred]
        • (chemotherapy,colon,iii,neutropenia) [inferred]
        • (chemotherapy,colon,tumor) [inferred]
        • (chemotherapy,iii,resection) [inferred]
        • (chemotherapy,pathologic,tumor) [inferred]
        • (chemotherapy,hand-foot,risk) [inferred]
        • (chemotherapy,colorectal,pulmonary) [inferred]
        • (chemotherapy,preoperative,tumor) [inferred]
        • (chemotherapy,iii,resected) [inferred]
        • (chemotherapy,colon,resected,tumor) [inferred]
        • (chemotherapy,mismatch,tumor) [inferred]
        • (chemotherapy,iii,tomography) [inferred]
        • (chemotherapy,resected,risk) [inferred]
        • (chemotherapy,resectable,resection) [inferred]
        • (chemotherapy,iii,posttreatment) [inferred]
        • (chemotherapy,iii,progression-free) [inferred]
        • (chemotherapy,metastases,resectable) [inferred]
        • (chemotherapy,colorectal,tumor) [inferred]
        • (chemotherapy,colon,resected,risks) [inferred]
        • (chemotherapy,colon,metastases) [inferred]
        • (chemotherapy,colon,fluorouracil,iii) [inferred]
        • (chemotherapy,resection,tumor) [inferred]
        • (chemotherapy,perineural,resected) [inferred]
        • (chemotherapy,resected,tumor) [inferred]
        • (chemotherapy,colorectal,registries) [inferred]
        • (chemotherapy,iii,tumors) [inferred]
        • (chemotherapy,pulmonary,resection) [inferred]
        • (chemotherapy,prognostic) [inferred]
        • (chemotherapy,colon,iii,intravenously) [inferred]
        • (chemotherapy,preoperative,resection) [inferred]
        • (chemotherapy,pathologic,resection) [inferred]
        • (chemotherapy,resected,stratification) [inferred]
        • (chemotherapy,colon,iii,infusional) [inferred]
        • (chemotherapy,clinicopathologic,colon,resected) [inferred]
        • (chemotherapy,iii,prognostication) [inferred]
        • (chemotherapy,colon,unresectable) [inferred]
        • (chemotherapy,colon,resected,stratification) [inferred]
        • (chemotherapy,clinicopathologic,risk) [inferred]
        • (chemotherapy,colon,perineural,resected) [inferred]
        • (chemotherapy,iii,tumor) [inferred]
        • (chemotherapy,loss,risk) [inferred]
        • (chemotherapy,metastases,tumor) [inferred]
        • (chemotherapy,iii,risk) [inferred]
        • (chemotherapy,resected,risks) [inferred]
        • (chemotherapy,resected,tumor-related) [inferred]
        • (chemotherapy,colon,iii,risk) [inferred]
        • (chemotherapy,resected,treatment-related) [inferred]
        • (chemotherapy,colon,oxaliplatin-based) [inferred]
        • (chemotherapy,colon,postoperative) [inferred]
        • (chemotherapy,colorectal,preoperative) [inferred]
        • (chemotherapy,metastases,registries) [inferred]
        • (chemotherapy,clinicopathologic,colon) [inferred]
        • (chemotherapy,colon,resection) [inferred]
        • (chemotherapy,neutropenia,risk) [inferred]
        • (chemotherapy,colon,resected,treatment-related) [inferred]

    • WIP (Read more)
      • Alternatively, the entire residual colon can be examined colonoscopically after resection. (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Colonoscopy'.)
        Family history
      • High Level Abstractions:
        • (colonoscopically,colorectal,resection)
        • Inferred entity relationships (31)
        • (colorectal,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,tumor) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (resection,risk) [inferred]
        • (resection,tumor) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (colorectal,risk) [inferred]

    • WIP (Read more)
      • PET scan may be helpful for patients who are thought to be candidates for resection of isolated colorectal cancer liver and lung metastases, in whom the routine use of PET reduces the number of nontherapeutic laparotomies
      • High Level Abstractions:
        • (candidates,colorectal,metastases)
        • (candidates,colorectal,resection)
        • Inferred entity relationships (38)
        • (metastases,polyp,resection) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (metastases,pulmonary,resection) [inferred]
        • (candidates,colon,resection) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,tumor) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (resection,risk) [inferred]
        • (resection,tumor) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (candidates,colorectal,metastases) [inferred]
        • (colorectal,msi) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (candidates,colorectal,resection) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (metastases,metastatic,resection) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (colorectal,risk) [inferred]

    • WIP (Read more)
      • (See "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Clinical manifestations and diagnosis" and "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Cancer screening and management".)
        Extracolonic cancers are very common in Lynch syndrome, particularly endometrial carcinomas, which may occur in up to 60 percent of female mutation carriers in some families
      • High Level Abstractions:
        • (manifestations,risk)
        • (cancers,colorectal,nonpolyposis)
        • (colorectal,risk)
        • (cancers,nonpolyposis)
        • (nonpolyposis,risk)
        • Inferred entity relationships (73)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (risk,tumor) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (nonpolyposis,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,loss) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colorectal,manifestations) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colorectal,tumor) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,mmr) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (risk,service) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]
        • (colorectal,risk) [inferred]

    • WIP (Read more)
      • A family history of colorectal and other extracolonic cancers (going back three generations if possible, but at least first- and second-degree relatives) should be sought, as the patient may be a member of a kindred with a hereditary predisposition.
      • High Level Abstractions:
        • (cancers,colorectal,predisposition)
        • Inferred entity relationships (69)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,loss) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colorectal,manifestations) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colorectal,tumor) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,mmr) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]
        • (colorectal,risk) [inferred]

    • WIP (Read more)
      • (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Colonoscopy'.)
        Family history. A family history of colorectal and other extracolonic cancers (going back three generations if possible, but at least first- and second-degree relatives) should be sought, as the patient may be a member of a kindred with a hereditary predisposition
      • High Level Abstractions:
        • (cancers,colorectal,extracolonic)
        • Inferred entity relationships (69)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,loss) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (colorectal,manifestations) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (colorectal,metastases,web-based) [inferred]
        • (cancers,carcinoma) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (cancers,histology,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (colorectal,tumor) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,mmr) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]
        • (colorectal,risk) [inferred]

    • WIP (Read more)
      • This finding could alter the surgical approach, prompting consideration of subtotal or total colectomy in high-risk individuals. (See 'Genetic issues'below and "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Clinical manifestations and diagnosis" and "MUTYH-associated polyposis", section on 'Colonic manifestations'.)
        However, use of family history alone is not sufficient to identify most patients with a hereditary colon cancer syndrome, particularly Lynch syndrome
      • High Level Abstractions:
        • (colorectal,nonpolyposis,subtotal)
        • (colorectal,individuals,nonpolyposis)
        • Inferred entity relationships (32)
        • (colorectal,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (nonpolyposis,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,tumor) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (individuals,security) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (individuals,monetary,policy) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (colorectal,risk) [inferred]

    • WIP (Read more)
      • (See 'Genetic issues'below and "Lynch syndrome (hereditary nonpolyposis colorectal cancer): Clinical manifestations and diagnosis", section on 'Tumor-based strategies'.)
        MANAGEMENT OF LOCALIZED DISEASE
        Surgical resection.
      • High Level Abstractions:
        • (colorectal,nonpolyposis,resection)
        • (colorectal,nonpolyposis,of_localized_disease)
        • (colorectal,nonpolyposis,strategies)
        • Inferred entity relationships (32)
        • (colorectal,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (nonpolyposis,risk) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,tumor) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (resection,risk) [inferred]
        • (resection,tumor) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (colorectal,risk) [inferred]

    • WIP (Read more)
      • (See 'Diagnosis'above.)
        .The combined American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) eighth edition tumor, node, metastasis (TNM) staging for colorectal cancer is illustrated in the table (table 1). (See 'Staging'above.)
        .Pretreatment clinical staging is best accomplished by physical examination and computed tomography (CT) scan of the chest, abdomen, and pelvis
      • High Level Abstractions:
        • (colorectal,tumor)
        • Inferred entity relationships (28)
        • (colorectal,metastases,web-based) [inferred]
        • (colorectal,nonpolyposis,strategies) [inferred]
        • (colorectal,preoperative,resection) [inferred]
        • (colorectal,metastases,visualized) [inferred]
        • (colorectal,individuals,nonpolyposis) [inferred]
        • (colorectal,loss) [inferred]
        • (colorectal,nonpolyposis,syndromes) [inferred]
        • (colorectal,metastases,preoperative) [inferred]
        • (colorectal,long-term,resection) [inferred]
        • (colorectal,national_comprehensive_cancer_network,resection) [inferred]
        • (colorectal,palliation,resection) [inferred]
        • (colorectal,metastases,resectable) [inferred]
        • (colorectal,metastases,tumor) [inferred]
        • (colorectal,msi) [inferred]
        • (colorectal,resectable,resection) [inferred]
        • (colorectal,nonpolyposis,risk) [inferred]
        • (colorectal,nonpolyposis,polyposis) [inferred]
        • (colorectal,metastases,resection) [inferred]
        • (colorectal,manifestations) [inferred]
        • (colorectal,nonpolyposis,subtotal) [inferred]
        • (colorectal,manifestations,nonpolyposis) [inferred]
        • (colorectal,metastases,pulmonary) [inferred]
        • (colorectal,mmr) [inferred]
        • (colorectal,nonpolyposis,of_localized_disease) [inferred]
        • (colorectal,nonpolyposis,resection) [inferred]
        • (colorectal,resectable) [inferred]
        • (colorectal,pulmonary,resection) [inferred]
        • (colorectal,risk) [inferred]

    • WIP (Read more)
      • (See "Clinical presentation, diagnosis, and staging of colorectal cancer", section on 'Metastatic disease'.)
        Although major advances in systemic chemotherapy have expanded the therapeutic options for these patients and improved median survival from less than one year in the single-agent fluoropyrimidine era to more than 30 months, fewer than 20 percent [23] of those treated with chemotherapy alone are still alive at five years, and only a few are free of disease, unless resection or ablation of metastases has been performed. (See "Systemic chemotherapy for metastatic colorectal cancer: General principles", section on 'Chemotherapy versus supportive care'and "Systemic chemotherapy for metastatic colorectal cancer: General principles".)
        On the other hand, surgery provides a potentially curative option for selected patients with limited metastatic disease, predominantly in the liver and lung
      • High Level Abstractions:
        • (metastases,metastatic,resection)
        • Inferred entity relationships (5)
        • (metastases,polyp,resection) [inferred]
        • (metastases,preoperative,resection) [inferred]
        • (resection,risk) [inferred]
        • (resection,tumor) [inferred]
        • (metastases,pulmonary,resection) [inferred]

    • WIP (Read more)
      • (See 'Surgical resection'above and 'Management of carcinoma in a polyp'above.)
        There is no consensus as to which patients, if any, are suitable for neoadjuvant approaches rather than upfront surgery
      • High Level Abstractions:
        • (cancers,polyp,resection)
        • (polyp,resection)
        • (cancers,carcinoma,resection)
        • Inferred entity relationships (45)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (resection,risk) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (cancers,histology,resection) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (polyp,risk) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (resection,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,mmr) [inferred]
        • (polyp,resection) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]

    • WIP (Read more)
      • Six months of therapy has been the standard approach, but the cumulative and dose-limiting neuropathy associated with oxaliplatin has prompted interest in a shorter duration of therapy. Results from the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) collaboration (six randomized trials of six versus three months of oxaliplatin-based adjuvant therapy) suggest that six months of therapy remains the standard of care for individuals with high-risk cancers (T4 or N2 (table 1)) [16]
      • High Level Abstractions:
        • (adjuvant,neuropathy)
        • (adjuvant,oxaliplatin)
        • Inferred entity relationships (59)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (oxaliplatin,resected) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (adjuvant,resected) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • WIP (Read more)
      • In addition, grade 3 sensory neuropathy developed in 13 percent during therapy but was still present at 48 months in fewer than 1 percent [19].
        .The substitution of capecitabine for infusional FU/LV in combination with oxaliplatin increases the convenience of treatment but tends to be more toxic than FOLFOX. As an example, in one adjuvant trial, rates of grade 3 or worse toxicity with CAPOX included diarrhea (19 percent), sensory neuropathy (11 percent), neutropenia (9 percent), vomiting (6 percent), hand-foot syndrome (5 percent), and dehydration (3 percent) [20]
      • High Level Abstractions:
        • (adjuvant,neuropathy)
        • (adjuvant,oxaliplatin)
        • Inferred entity relationships (59)
        • (adjuvant,chemotherapy,colon,risk) [inferred]
        • (adjuvant,risk) [inferred]
        • (adjuvant,chemotherapy,iii) [inferred]
        • (adjuvant,oxaliplatin-based) [inferred]
        • (adjuvant,colon,rectal) [inferred]
        • (adjuvant,iii,oxaliplatin) [inferred]
        • (adjuvant,iii,risk) [inferred]
        • (adjuvant,clinicopathologic,colon) [inferred]
        • (adjuvant,colorectal,metastases) [inferred]
        • (oxaliplatin,resected) [inferred]
        • (adjuvant,chemotherapy,clinicopathologic,colon) [inferred]
        • (adjuvant,colon,oxaliplatin-based) [inferred]
        • (adjuvant,chemotherapy,colon,oxaliplatin-based) [inferred]
        • (adjuvant,chemotherapy,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,treatment-related) [inferred]
        • (adjuvant,colon,rectal,resected) [inferred]
        • (adjuvant,colon,resected,risks) [inferred]
        • (adjuvant,iii,multidisciplinary) [inferred]
        • (adjuvant,colon,preoperative) [inferred]
        • (adjuvant,colon,resected,tumor-related) [inferred]
        • (adjuvant,colon,treatment-related) [inferred]
        • (adjuvant,chemotherapy,colon,volume) [inferred]
        • (adjuvant,colon,tumor) [inferred]
        • (adjuvant,resection) [inferred]
        • (adjuvant,prognostic) [inferred]
        • (adjuvant,iii,postoperative) [inferred]
        • (adjuvant,chemotherapy,preoperative) [inferred]
        • (adjuvant,colon,resected,transmural) [inferred]
        • (adjuvant,chemotherapy,resected) [inferred]
        • (adjuvant,chemotherapy,risk) [inferred]
        • (adjuvant,iii,neuropathy) [inferred]
        • (adjuvant,oxaliplatin) [inferred]
        • (adjuvant,iii,tumors) [inferred]
        • (adjuvant,chemotherapy,colon,risks) [inferred]
        • (adjuvant,colon,risk) [inferred]
        • (adjuvant,iii,resected) [inferred]
        • (adjuvant,chemotherapy,colon,iii) [inferred]
        • (adjuvant,colon,perineural,resected) [inferred]
        • (adjuvant,iii,resection) [inferred]
        • (adjuvant,chemotherapy,oxaliplatin-based) [inferred]
        • (adjuvant,iii,tumor) [inferred]
        • (adjuvant,colon,iii) [inferred]
        • (adjuvant,colon,resected,treatment-related) [inferred]
        • (adjuvant,chemotherapy,risks) [inferred]
        • (adjuvant,disease-free,iii) [inferred]
        • (adjuvant,chemotherapy,prognostic) [inferred]
        • (adjuvant,colon,risks) [inferred]
        • (adjuvant,resected) [inferred]
        • (adjuvant,chemotherapy,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,resected) [inferred]
        • (adjuvant,colon,iii,resected) [inferred]
        • (adjuvant,colon,resected,tumor) [inferred]
        • (adjuvant,tumor) [inferred]
        • (adjuvant,treatment-related) [inferred]
        • (adjuvant,colon,resected,risk) [inferred]
        • (adjuvant,neuropathy) [inferred]
        • (adjuvant,chemotherapy,colon,tumor) [inferred]
        • (adjuvant,chemotherapy,colon,preoperative) [inferred]
        • (adjuvant,chemotherapy,resection) [inferred]

    • WIP (Read more)
      • The benefit of chemotherapy for resected stage II disease is controversial, and treatment decisions must be individualized. (See 'Adjuvant chemotherapy'above.)
        .Chemotherapy carries a risk of significant toxicities, including mucositis, emesis, diarrhea, febrile neutropenia, fatigue, hair loss, hand-foot syndrome, and cardiotoxicity
      • High Level Abstractions:
        • (resected,risk)
        • Inferred entity relationships (3)
        • (risk,tumor) [inferred]
        • (resected,risks) [inferred]
        • (risk,service) [inferred]

    • WIP (Read more)
      • Benign adenomas, as well as those with severe dysplasia or carcinoma in situ (no evidence of invasive cancer, defined as invasion into the submucosa), can be effectively managed by endoscopic removal (polypectomy) alone as long as the resection margins are free of cancer
      • High Level Abstractions:
        • (cancers,carcinoma,resection)
        • (cancers,resection,situ)
        • (cancers,resection,submucosa)
        • Inferred entity relationships (43)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,histology,resection) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (resection,risk) [inferred]
        • (resection,tumor) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]
        • (cancers,risk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]

    • WIP (Read more)
      • (See 'Posttreatment surveillance'above.)
        .Regularly updating a three-generation family history pedigree from cancer survivors can be valuable to help determine the potential risk of cancer in family members, as well as the survivor's own risk of subsequent cancers that may be associated with a previously unrecognized hereditary syndrome
      • High Level Abstractions:
        • (cancers,risk)
        • Inferred entity relationships (42)
        • (cancers,colon,histology) [inferred]
        • (cancers,resection,submucosa) [inferred]
        • (risk,tumor) [inferred]
        • (cancers,carcinoma) [inferred]
        • (cancers,colorectal,extracolonic) [inferred]
        • (cancers,colon,colorectal) [inferred]
        • (cancers,histology,resection) [inferred]
        • (cancers,colorectal,predisposition) [inferred]
        • (cancers,loss) [inferred]
        • (cancers,resection,submucosal) [inferred]
        • (cancers,carcinoma,resection) [inferred]
        • (cancers,colon,polyp) [inferred]
        • (cancers,colorectal,ihc) [inferred]
        • (cancers,colectomy,colon) [inferred]
        • (cancers,colon,nonobstructed) [inferred]
        • (cancers,colorectal,nonpolyposis) [inferred]
        • (cancers,colorectal,individuals) [inferred]
        • (cancers,colectomy,resection) [inferred]
        • (cancers,chemotherapy,colon) [inferred]
        • (cancers,colon,preoperative) [inferred]
        • (cancers,colorectal,pms) [inferred]
        • (cancers,polyp,resection) [inferred]
        • (cancers,resection,subtotal) [inferred]
        • (cancers,colon,resection) [inferred]
        • (cancers,msi) [inferred]
        • (cancers,polyp) [inferred]
        • (cancers,oxaliplatin-based) [inferred]
        • (cancers,colorectal,msi) [inferred]
        • (cancers,mmr) [inferred]
        • (cancers,colon,iii) [inferred]
        • (cancers,nonpolyposis) [inferred]
        • (cancers,resection,situ) [inferred]
        • (cancers,colon,oxaliplatin-based) [inferred]
        • (cancers,colon,resected) [inferred]
        • (cancers,colorectal,loss) [inferred]
        • (cancers,colorectal,sporadic) [inferred]
        • (cancers,lymphovascular,resection) [inferred]
        • (risk,service) [inferred]
        • (cancers,colorectal,mmr) [inferred]
        • (cancers,resection,stalk) [inferred]
        • (cancers,chemotherapy) [inferred]
        • (cancers,colon,lymphovascular) [inferred]

    Target rule match count: 338.0 Challenge: 0.18 Momentum: 0.04 WIP: 0.28